(4-硝基苯胺基)脲 | 16246-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-硝基苯胺基)脲
• 英文名称: 4-nitrophenylsemicarbazide
• 英文别名: 1-(p-Nitro-phenyl)-semicarbazid；1-<4-Nitro-phenyl>-semicarbazid；1-(4-nitro-phenyl)-semicarbazide；1-(4-Nitro-phenyl)-semicarbazid；2-(4-Nitrophenyl)hydrazine-1-carboxamide；(4-nitroanilino)urea
• CAS: 16246-34-7
• 化学式: C₇H₈N₄O₃
• 分子量: 196.166
• InChiKey: MXKOEIVLFHOVHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-硝基苯胺基)脲 在 palladium on activated charcoal 硫酸 、 氢气 、 sodium hydride 作用下， 以 乙醇 为溶剂， 25.0~100.0 ℃ 、101.33 kPa 条件下， 反应 20.33h， 生成 1-(4-aminophenyl)-3-propoxy-1H-1,2,4-triazole
  参考文献：
  名称：

  Synthesis and anti-myxovirus activity of some novel N,N′-disubstituted thioureas

  摘要：

  A series of new N,N'-disubstituted thioureas were prepared and evaluated in vitro for their activity against myxoviruses. Compound N-[4-(3-propoxy-1H-1,2,4-triazol-1-yl)phenyl]-Ar-(2-pyrazinyl)thiourea 5d exhibited specific activity against respiratory syncytial virus in HeLa cells. Compounds N-(1-adamantanyl)-N'-[4-(3-ethoxy-1H-1,2,4-triazol-1-yl)phenyl]thiourea 5g and N-(1-adamantanyl)-N'-[4-(3-propoxy-1H-1,2,4-triazol-1-yl)phenyl]thiourea 5h proved active against influenza A in Madin-Darby canine kidney (MDCK) cells and respiratory syncytial virus in HeLa cells.

  DOI：

  10.1016/0223-5234(94)90209-7
• 作为产物：
  描述：

  potassium cyanate 、 4-硝基苯肼盐酸盐 在 水 作用下， 生成 (4-硝基苯胺基)脲
  参考文献：
  名称：

  Hyde, Chemische Berichte, 1899, vol. 32, p. 1813

  摘要：

  DOI：

文献信息

• Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety
  作者：Seref Demirayak、Ismail Kayagil、Leyla Yurttas、Sevda Er

  DOI：10.2174/1570180812666150723001545

  日期：2015.11.12

  A series of new N’-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1- 16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4- substitutedarylhydrazine derivatives and the structures of final compounds

  制备并测试了一系列新的N'-（亚芳基）-2-[（1-（4-硝基苯基）-1H-1,2,4-三唑-3-基）氧基]乙酰肼衍生物（1-1）对六种植物病原体，三种人类病原体和两种非病原微生物的杀真菌活性。从4-取代的芳基肼衍生物开始，通过多步反应获得目标化合物，并通过IR，NMR，质谱数据和元素分析结果阐明了最终化合物的结构。采用微量稀释法测定了该化合物对11种镰刀菌，木霉菌，曲霉和青霉菌的抗真菌活性。大多数目标化合物对多种真菌病原体均显示出优异的抗真菌活性。
• [EN] COMPOSITION FOR INHIBITING MICRO-ORGANISMS<br/>[FR] COMPOSITION D'INHIBITION DE MICRO-ORGANISMES
  申请人：CLARIANT INT LTD

  公开号：WO2019115478A1

  公开（公告）日：2019-06-20

  The present invention relates to a composition for inhibiting micro-organisms, as well as related processes, formulations, concentrates and uses. The composition comprises at least 30 wt.-% compound X, wherein compound X is according to Formula (I) wherein R is an unsaturated hydrocarbon chain having 5 to 13 carbon atoms; and wherein R1 is -H or a C1-6 unsubstituted alkyl moiety, preferably R1 is methyl.

  本发明涉及一种用于抑制微生物的组合物，以及相关的工艺、配方、浓缩物和用途。该组合物包括至少30重量％的化合物X，其中化合物X符合以下化学式(I)，其中R是具有5至13个碳原子的不饱和碳氢链；R1为-H或C1-6未取代烷基基团，最好R1为甲基。
• [EN] COMPOSITION FOR INHIBITING MICRO-ORGANISMS<br/>[FR] COMPOSITION POUR L'INHIBITION DE MICRO-ORGANISMES
  申请人：CLARIANT INT LTD

  公开号：WO2018002100A1

  公开（公告）日：2018-01-04

  The present invention relates to a composition for inhibiting micro-organisms, as well as related processes, formulations, concentrates and uses. The composition comprises at least 30 wt.-% compound X, wherein compound X is according to Formula (I): wherein R is a saturated or unsaturated hydrocarbon chain having seven or nine carbon atoms, or a mixture thereof.

  本发明涉及一种抑制微生物的组合物，以及相关的过程、配方、浓缩物和用途。该组合物包含至少30重量％的化合物X，其中化合物X符合公式（I）：其中R是具有七个或九个碳原子的饱和或不饱和碳氢链，或其混合物。
• Dye-containing pellets and their use
  申请人：Wella Aktiengesellschaft

  公开号：EP1820487A1

  公开（公告）日：2007-08-22

  The present patent application relates to dye-containing pellets obtained by (a) homogeneous mixing of a starting material containing at least one natural and/or synthetic dye with a suitable carrier material and then coating with a suitable encapsulation material or (b) coating a suitable carrier material with a mixture of at least one natural and/or synthetic dye and at least one suitable, encapsulation material, to the use of said pellets for preparing colorants for keratin fibers and to the colorants based on said pellets. Furthermore the present patent application relates to the use of these pellets for increasing the shine of the keratin fibers, reducing the scalp colouring of hair dyes, improving the protection for the cortex, increasing the colourant efficiency and reducing the load of colourants, and improving the wash resistance.

  本专利申请涉及通过以下方法获得的含染料颗粒：(a) 将含有至少一种天然和/或合成染料的起始材料与适当的载体材料均匀混合，然后涂上适当的封装材料，或 (b) 在适当的载体材料上涂上至少一种天然和/或合成染料与至少一种适当的封装材料的混合物；使用所述颗粒制备角蛋白纤维着色剂；以及基于所述颗粒的着色剂。此外，本专利申请还涉及使用这些颗粒增加角蛋白纤维的光泽，减少染发剂对头皮的染色，改善对皮质的保护，提高染色剂的效率，减少染色剂的负荷，以及改善耐洗性。
• Method and composition for reducing the drying time of hair
  申请人：Wella Aktiengesellschaft

  公开号：EP2090295A1

  公开（公告）日：2009-08-19

  The invention concerns to a method and composition for improving the drying time of hair, for example, after bathing, shampooing, swimming, and the like by impregnating it with a particular amino functional silicon derivative. In a preferred embodiment the invention concerns to hair styling compositions that are applied to dry or wet hair as a leave-in treatment and that additionally reduces the time to dry the hair during styling; further to leave-in or rinse-out hair care compositions that additionally reduces the time to dry the hair.

  本发明涉及一种改善头发干燥时间的方法和组合物，例如，在沐浴、洗发、游泳等之后，用特定的氨基功能硅衍生物浸渍头发。在一个优选的实施方案中，本发明涉及一种用于干发或湿发的头发定型组合物，该组合物可作为免洗护理剂使用，并可在定型过程中额外缩短头发的干燥时间；本发明还涉及一种免洗或冲洗型头发护理组合物，该组合物可额外缩短头发的干燥时间。