(9ci)-1-羟基-1H-苯并咪唑-2-羧酸3-氧化物 | 34759-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: (9ci)-1-羟基-1H-苯并咪唑-2-羧酸3-氧化物
• 英文名称: 1-Hydroxy-3-oxobenzimidazol-2-carbonsaeure
• 英文别名: 1-hydroxy-3-oxy-1H-benzoimidazole-2-carboxylic acid；2-carboxy-3-hydroxy-3H-benzo[d]imidazole-1-oxide；1-Hydroxy-3-oxo-1H-3,1-benzimidazole-2-carboxylic acid；1-hydroxy-3-oxidobenzimidazol-3-ium-2-carboxylic acid
• CAS: 34759-73-4
• 化学式: C₈H₆N₂O₄
• 分子量: 194.147
• InChiKey: RHQSTHZCUWNEGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

文献信息

• [EN] COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS<br/>[FR] COMPOSÉS INHIBITEURS D'ENZYME LACTATE DÉSHYDROGÉNASE (LDH) ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSÉS
  申请人：UNIV PISA

  公开号：WO2011054525A1

  公开（公告）日：2011-05-12

  The present invention concerns compounds, some of which are novel, and their pharmaceutical applications. The compounds of the invention inhibit the enzyme lactate dehydrogenase (LDH) involved both in the metabolic process of hypoxic tumour cells, and in the process used by parasitic protozoa that cause malaria to obtain most of the energy they need.

  这项发明涉及化合物，其中一些是新颖的，以及它们的药用应用。该发明的化合物抑制乳酸脱氢酶（LDH）酶，该酶参与低氧肿瘤细胞的代谢过程，以及疟疾引起的寄生原虫利用获取所需大部分能量的过程。
• Rubber compositions modified with hydroxy-benzimidazole oxides
  申请人：THE FIRESTONE TIRE & RUBBER COMPANY

  公开号：EP0287806A1

  公开（公告）日：1988-10-26

  It now has been found that the properties of rubber compositions comprising rubbers having an unsaturated carbon chain can be improved by including therein, a minor property-improving amount of at least one hydroxy-benzimidazole oxide compound of the formula wherein R is hydrogen, or a halogen, hydroxyl, lower acyl, lower hydrocarbyl, lower hydrocarbyloxy, lower hydrocarbylthio, carboxyl, cyano, amino, amide or -C(O)- ­lower hydrocarbyl group, and Rʹ is hydrogen, or a lower hydrocarbyl, lower hydrocarbyl amide, carboxamide carboxy acid, carboxy ester, or aryl group. When vulcanizates are prepared from such rubber compositions containing one or more fillers, the vulcanizates exhibit reduced low strain hysteresis and a high electrical resistivity. In another aspect of the invention, a filled vulcanizate made by vulcanizing uncured compositions of the type described above and containing a filler, particularly carbon black, is improved in filler interaction, hysteresis, modulus, compression set and resiliency. Rubber articles and portions thereof such as tires, hoses, springs, belts, treads, sidewalls and the like can be made utilizing the improved filled vulcanizates of the invention.

  现已发现，通过在橡胶组合物中加入少量的至少一种羟基氧化苯并咪唑化合物，可改善橡胶组合物的性能，该化合物具有不饱和碳链 其中 R 是氢、或卤素、羟基、低级酰基、低级烃基、低级烃氧基、低级烃硫基、羧基、氰基、氨基、酰胺或 -C(O)- 低级烃基，Rʹ 是氢、或低级烃基、低级烃酰胺、羧酰胺、羧酸、羧酸酯或芳基。当用含有一种或多种填料的此类橡胶组合物制备硫化胶时，硫化胶表现出较低的应变滞后性和较高的电阻率。 在本发明的另一个方面，通过硫化上述类型的未硫化组合物和含有填料（尤其是炭黑）的填充硫化胶，可改善填料相互作用、滞后、模量、压缩永久变形和回弹性。利用本发明的改进型填充硫化胶，可制成橡胶制品及其部分，如轮胎、软管、弹簧、皮带、胎面、侧壁等。
• Process, modified rubbers and rubber compositions
  申请人：THE FIRESTONE TIRE & RUBBER COMPANY

  公开号：EP0319733A2

  公开（公告）日：1989-06-14

  It now has been found that uncured modified rubber compositions comprising mixtures of elastomers and a reinforcing filler can be prepared having improved properties. More particularly, such uncured modified rubber compositions can be prepared by a process which comprises the steps of (A) preparing a first mixture comprising an elastomer, at least one reinforcing filler and at least one chemical agent capable of promoting the formation of filler-elastomer linkages; (B) preparing a second mixture comprising (i) an elastomer, at least one reinforc­ing filler and at least one chemical agent capable of promoting the forma­tion of filler-elastomer linkages, wherein at least one of the elastom­er, filler or chemical agent in the second mixture is different from the elastomer, filler or chemical agent in the first mixture; or (ii) an elastomer and at least one rein­forcing filler; or (iii) at least one reinforcing filler and at least one chemical agent capable of promoting the formation of fil­ler-elastomer linkages; or (iv) an elastomer and at least one chemi­cal agent capable of promoting the formation of filler-elastomer link­ages; and (C) blending the first and second mixtures to form a third mixture. Examples of such useful chemical agents include aromatic furazan oxides, heterocyclic di-N-oxides, 1-hydroxy-ben­zimidazole-3-oxide compounds, 1,3-dihydroxy-benzimidazol­inone compounds, and aromatic nitroso compounds. The invention also includes filled vulcanizates prepared by vulcanizing the uncured modified rubber com­positions prepared in accordance with the above method. Rubber articles and portions thereof made from such vul­canizates such as tires, hoses, belts, treads, sidewalls and the like are also within the scope of the present invention as well as methods of reducing the rolling resistance of tires.

  现在已经发现，由弹性体和补强填料混合物组成的未固化改性橡胶组合物可以制备出性能更好的产品。更具体地说，这种未固化改性橡胶组合物可通过以下步骤制备 (A) 制备第一种混合物，其中包括弹性体、至少一种补强填料和至少一种能够促进填料-弹性体连接形成的化学剂； (B) 制备第二种混合物，包括 (i) 弹性体、至少一种增强填料和至少一种能促进形成填料-弹性体联结 的化学剂，其中第二种混合物中的至少一种弹性体、填料或化学剂 不同于第一种混合物中的弹性体、填料或化学剂；或 (ii) 弹性体和至少一种增强填料；或 (iii) 至少一种增强填料和至少一种能促进填料-弹性体连接形成的化学剂；或 (iv) 弹性体和至少一种能促进形成填料-弹性体连接的化学剂；以及 (C) 混合第一和第二混合物，形成第三混合物。 此类有用化学剂的例子包括芳香族呋喃氧化物、杂环二-N-氧化物、1-羟基-苯并咪唑-3-氧化物化合物、1,3-二羟基-苯并咪唑啉酮化合物和芳香族亚硝基化合物。 本发明还包括通过硫化根据上述方法制备的未硫化改性橡胶组合物而制备的填充硫化胶。由此类硫化胶制成的橡胶制品及其部分，如轮胎、软管、皮带、胎面、侧壁等，以及降低轮胎滚动阻力的方法，也属于本发明的范围。
• COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
  申请人：Universita Di Pisa

  公开号：EP2499114A1

  公开（公告）日：2012-09-19
• US4762870A
  申请人：——

  公开号：US4762870A

  公开（公告）日：1988-08-09