N-[[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-1-methylpyrrolidin-2-yl]methyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-[[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-1-methylpyrrolidin-2-yl]methyl]acetamide
• 化学式: C₉H₁₈N₂O₄
• 分子量: 218.25
• InChiKey: GUYSAAUIAYZIMA-FUZJYRNYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  93
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS SÉLECTIFS DE LA GLYCOSIDASE ET LEURS UTILISATIONS
  申请人：UNIV FRASER SIMON

  公开号：WO2010037207A1

  公开（公告）日：2010-04-08

  The application relates to an immoalditol compound for selectively inhibiting glycosidases, a prodrug thereof and a pharmaceutical composition comprising the compound or the prodrug The application also relates to the use of the immoalditol compound for treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-G1cNAc Such diseases and disorders include neurodegenerative diseases, tauopathy, cancers, and cardiac disorders