cyclic-Cidofovir

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: cyclic-Cidofovir
• 英文别名: 4-amino-1-[[(5R)-2-hydroxy-2-oxo-1,4,2λ5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one
• 化学式: C₈H₁₂N₃O₅P
• 分子量: 261.17
• InChiKey: YXQUGSXUDFTPLL-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Phosphonate compounds
  申请人：Hostetler Y. Karl

  公开号：US20070161602A1

  公开（公告）日：2007-07-12

  The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

  本发明涉及膦酸盐化合物、含有它们的组合物、获得它们的过程及其用于治疗多种医学疾病的用途，例如骨质疏松症和其他骨代谢紊乱、癌症、病毒感染等。
• Phosphonate Compounds
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIF

  公开号：US20130045950A1

  公开（公告）日：2013-02-21

  The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

  本发明涉及磷酸酯化合物、含有它们的组合物、制备它们的过程以及它们用于治疗各种医学疾病，例如骨质疏松症和其他骨代谢紊乱、癌症、病毒感染等。
• PHOSPHONATE COMPOUNDS
  申请人：The Regents of the University of California

  公开号：US20160067268A1

  公开（公告）日：2016-03-10

  The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

  本发明涉及膦酸盐化合物、含有它们的组合物、制备它们的过程以及它们用于治疗各种医学疾病的用途，例如骨质疏松症和其他骨代谢紊乱、癌症、病毒感染等。
• Compounds, compositions and methods for the treatment of poxvirus infections
  申请人：Almond R. Merrick

  公开号：US20070003516A1

  公开（公告）日：2007-01-04

  The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections, such as orthopox virus infections. In one embodiment, a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir, cyclic cidofovir, or a salt, ester, or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is, for example, a biologic, such as a pegylated interferon.
• US8642577B2
  申请人：——

  公开号：US8642577B2

  公开（公告）日：2014-02-04