1,7-Bis(4-hydroxyphenyl)-1-heptene-3,5-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1,7-Bis(4-hydroxyphenyl)-1-heptene-3,5-dione
• 英文别名: (E)-1,7-bis(4-hydroxyphenyl)hept-1-ene-3,5-dione
• 化学式: C₁₉H₁₈O₄
• 分子量: 310.3
• InChiKey: AWUBJLRYWHOLFW-VZUCSPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHOD TO PREPARE PURE CURCUMIN
  申请人：Kim Darrick S.H.L.

  公开号：US20100048957A1

  公开（公告）日：2010-02-25

  This invention describes a preparation of at least 99% by weight pure curcumin from less pure grades of curcumin utilizing phenol protecting groups to favor a selective recrystallization of curcumin in the presence of demethoxycurcumin and bis-demethoxycurcumin and other curcuminoids of minor composition.

  这项发明描述了利用酚保护基从较不纯的姜黄素中制备至少99%重量纯度的姜黄素，利用酚保护基有利于在去甲氧基姜黄素、双去甲氧基姜黄素和其他少量成分的姜黄素存在下选择性地重新结晶姜黄素。
• Shunt delivery of curcumin for the treatment Alzneimer
  申请人：Codman & Shurtleff, Inc.

  公开号：EP2359820A1

  公开（公告）日：2011-08-24

  A method for reducing or preventing a human brain disorder relating to the presence of a pathogenic substance in cerebrospinal fluid by selecting a human for treatment as a patient and placing a proximal end of a first catheter, having at least a first lumen, in a first sub-dural location within the brain of the patient to establish open communication between the first lumen and cerebrospinal fluid of the patient. For an extended period of time, a curcumin agent selected from at least one of curcumin, a curcumin hybrid and a curcumin analog is delivered to the cerebrospinal fluid to interact with the pathogenic substance to attenuate its effect on the brain.

  一种减少或预防与脑脊液中存在致病物质有关的人类脑部疾病的方法，其方法是选择人类作为患者进行治疗，并将具有至少第一管腔的第一导管的近端置于患者脑内的第一硬膜下位置，以建立第一管腔与患者脑脊液之间的开放式交流。在一段较长的时间内，选自姜黄素、姜黄素混合物和姜黄素类似物中至少一种的姜黄素制剂被输送到脑脊液中，与致病物质相互作用，以减弱其对大脑的影响。
• Curcumin-resveratrol hybrids
  申请人：Codman & Shurtleff, Inc.

  公开号：EP2749552A1

  公开（公告）日：2014-07-02

  Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer's disease.

  基于姜黄素和羟基二苯乙烯（如白藜芦醇）杂交的新型分子。相信这些新型分子在治疗阿尔茨海默氏症方面会有特殊用途。
• Probiotic and polyphenol against neurodegeneration
  申请人：NESTEC S.A.

  公开号：US10912803B2

  公开（公告）日：2021-02-09

  A composition containing the probiotic strain Lactobacillus johnsonii CNCM 1-1225 in combination with a polyphenol for use in the treatment or prevention of a cognitive and/or neurodegenerative disorder, in particular Alzheimer's disease. The polyphenol can be one or more of rosmarinic acid, chicoric acid, or caftaric acid, and can be provided in the form of a plant extract.

  一种含有益生菌株约翰逊乳杆菌 CNCM 1-1225 和一种多酚的组合物，用于治疗或预防认知和/或神经退行性疾病，特别是阿尔茨海默氏症。多酚可以是迷迭香酸、菊苣酸或茶檀酸中的一种或多种，可以植物提取物的形式提供。
• Methods for treatment of beta-amyloid protein-induced ocular disease
  申请人：Kim S. H. L. Darrick

  公开号：US20060148905A1

  公开（公告）日：2006-07-06

  The invention provides methods for treating beta-amyloid protein-involved ocular disease including age-related macular degeneration and glaucoma, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., and Rosmarinus sp. and synthetic chemical analogues thereof, for the treatment of a beta-amyloid protein-involved ocular disease.

  本发明提供了治疗β-淀粉样蛋白参与的眼部疾病（包括老年性黄斑变性和青光眼）的方法、药物组合物和对其有用的化合物，以及使用这些化合物制造治疗上述疾病的药物。更具体地说，本发明涉及从以下植物中分离出的天然产物化合物的用途 莪术 sp、 薑 sp、 银杏叶、丹参 和 蔷薇 及其合成化学类似物，用于治疗受β-淀粉样蛋白影响的眼部疾病。