(9ci)-2-(乙氧基甲基)-1H-苯并咪唑 | 80761-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: (9ci)-2-(乙氧基甲基)-1H-苯并咪唑
• 英文名称: 2-(ethoxymethyl)-1H-benzo[d]imidazole
• 英文别名: 2-ethoxymethyl-1H-benzimidazole；2-Aethoxymethyl-1H-benzimidazol；2-(ethoxymethyl)-1H-benzimidazole
• CAS: 80761-36-0
• 化学式: C₁₀H₁₂N₂O
• 分子量: 176.218
• InChiKey: VVJGFXIWZSDXFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (9ci)-2-(乙氧基甲基)-1H-苯并咪唑 生成 2-Ethoxymethyl-5-nitro-1H-benzoimidazole
  参考文献：
  名称：

  设计，合成和评估新型取代的苯并咪唑化合物作为血管紧张素II受体拮抗剂。

  摘要：

  已经设计，合成并评估了在2-位具有不同取代基的5-硝基苯并咪唑衍生物的血管紧张素II拮抗活性。已经提出了药物-受体相互作用模型。

  DOI：

  10.1016/j.bmcl.2005.05.054
• 作为产物：
  描述：

  乙氧基乙酸 、 邻苯二胺 生成 (9ci)-2-(乙氧基甲基)-1H-苯并咪唑
  参考文献：
  名称：

  设计，合成和评估新型取代的苯并咪唑化合物作为血管紧张素II受体拮抗剂。

  摘要：

  已经设计，合成并评估了在2-位具有不同取代基的5-硝基苯并咪唑衍生物的血管紧张素II拮抗活性。已经提出了药物-受体相互作用模型。

  DOI：

  10.1016/j.bmcl.2005.05.054

文献信息

• Ion Channel Modulators
  申请人：Zelle Robert

  公开号：US20070281937A1

  公开（公告）日：2007-12-06

  The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

  这项发明涉及化合物、包含这些化合物的组合物，以及使用这些化合物和化合物组合物的方法。本文描述的化合物、组合物和方法可用于治疗调节离子通道功能，以及治疗疾病和疾病症状，特别是那些由特定钙通道亚型靶点介导的疾病。
• MOLECULARLY IMPRINTED POLYMERS, METHODS FOR THEIR PRODUCTION AND USES THEREOF
  申请人：Hearn Milton T.W.

  公开号：US20120225962A1

  公开（公告）日：2012-09-06

  The present invention relates to methods of preparing molecularly imprinted polymers (MIPs) which facilitate chemical hydrolysis and more particularly the hydrolysis of chemical substrates which possess hydrolytically labile bonds such as peptides and proteins. The present invention is thus directed to MIPs designed to possess hydrolytic activity, methods for preparing such MIPs and uses of the MIPs.

  本发明涉及制备分子印迹聚合物（MIPs）的方法，该方法促进化学水解，更具体地，促进具有水解敏感键的化学底物（例如肽和蛋白质）的水解。因此，本发明针对设计具有水解活性的MIPs，制备这种MIPs的方法以及MIPs的用途。
• A unique one-pot reaction via CC cleavage from aminomethylene benzimidazoles to access benzimidazolones with wide potentiality
  作者：Hui-Zhen Zhang、Sheng-Feng Cui、Sangaraiah Nagarajan、Syed Rasheed、Gui-Xin Cai、Cheng-He Zhou

  DOI：10.1016/j.tetlet.2014.05.113

  日期：2014.7

  A unique one-pot reaction via C-C cleavage from aminomethylene benzimidazoles with commercial halides to access novel benzimidazolones is reported for the first time. The previously unexploited transformation is able to perform smoothly in the presence of commercial potassium carbonate, while the stronger inorganic bases or organic amines as catalysts are not favorable to the transformation. Significant influential factors including base, temperature, solvent, water content, and molar ratio of substrates to this reaction are investigated, and possibly mechanistic consideration is also discussed. Some synthesized benzimidazolones were evaluated and exhibited better bioactivities against tested strains than clinical drugs chloromycin, norfloxacin, and fluconazole. (C) 2014 Elsevier Ltd. All rights reserved.
• [EN] ION CHANNEL MODULATORS<br/>[FR] MODULATEURS DE CANAUX IONIQUES
  申请人：SCION PHARMACEUTICALS INC

  公开号：WO2005097112A2

  公开（公告）日：2005-10-20

  The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
• Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists
  作者：Alka Bali、Yogita Bansal、M. Sugumaran、Jatinder Singh Saggu、P. Balakumar、Gurpreet Kaur、Gulshan Bansal、Ajay Sharma、Manjeet Singh

  DOI：10.1016/j.bmcl.2005.05.054

  日期：2005.9

  5-Nitrobenzimidazole derivatives with varying substituents at 2-position have been designed, synthesized, and evaluated for angiotensin II antagonistic activity. A drug-receptor interaction model has been proposed.

  已经设计，合成并评估了在2-位具有不同取代基的5-硝基苯并咪唑衍生物的血管紧张素II拮抗活性。已经提出了药物-受体相互作用模型。