(4R,4aR,7S,7aR,12bS)-3-methyl-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7,9-diol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4R,4aR,7S,7aR,12bS)-3-methyl-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7,9-diol
• 化学式: C20H24NO3+
• 分子量: 326.4
• InChiKey: HJDWPCLBBHHTIG-MVRDOSEYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Method and product for inducing anorexia
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0005636A1

  公开（公告）日：1979-11-28

  Naltrexone or a pharmaceutically effective salt thereof is administered orally so as to effect appetite suppression in mammals.

  口服纳曲酮或其有效药用盐可抑制哺乳动物的食欲。
• COMPOSITIONS AND METHODS FOR TREATING OPIATE INTOLERANCE
  申请人：Cooper, Barrett R.

  公开号：EP1206264A2

  公开（公告）日：2002-05-22
• US4217353A
  申请人：——

  公开号：US4217353A

  公开（公告）日：1980-08-12
• [EN] COMPOSITIONS AND METHODS FOR TREATING OPIATE INTOLERANCE<br/>[FR] COMPOSITIONS ET PROCEDES PERMETTANT DE TRAITER L'INTOLERANCE AUX OPIACES
  申请人：COOPER BARRETT R

  公开号：WO2001013909A2

  公开（公告）日：2001-03-01

  Provided are compositions comprising an opiate analgesic and an active compound containing the R isomer of N-methylnalorphine in a pharmaceutically acceptable carrier. Also provided are methods of treating opiate intolerance by administration of an active compound containing R N-methylnalorphine or a pharmaceutically acceptable salt thereof. The active compound may be administered either acutely or chronically to subjects receiving opiate treatment. Further provided are methods of inducing analgesia by administering to a subject an opiate analgesic concurrently with an active compound containing R N-methylnalorphine or a pharmaceutically acceptable salt thereof.