(Cbz-肼基)三氟乙酸甘氨酸酯 | 19704-03-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (Cbz-肼基)三氟乙酸甘氨酸酯
• 中文别名: (CBZ-肼基)-甘胺酰三氟乙酸盐
• 英文名称: TFA*H-Gly-NHNHZ
• 英文别名: Glycin-benzyloxycarbonyl-hydrazid-trifluoracetat；Gly-Z-hydrazid-trifluoracetat；(Cbz-hydrazido)glycine trifluoroacetate salt；benzyl N-[(2-aminoacetyl)amino]carbamate;2,2,2-trifluoroacetic acid
• CAS: 19704-03-1
• 化学式: C₂HF₃O₂*C₁₀H₁₃N₃O₃
• mdl: MFCD00058603
• 分子量: 337.255
• InChiKey: ZYWUIPUGRJNRCM-UHFFFAOYSA-N

物化性质

• 熔点：
  175-178 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  131
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  (Cbz-肼基)三氟乙酸甘氨酸酯 、 Z-L-苯丙氨酸苄酯 在 subtilisin BPN' 、 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 以60%的产率得到Z-Phe-Gly-NHNHZ
  参考文献：
  名称：

  Exploitation of Subtilisin BPN‘ as Catalyst for the Synthesis of Peptides Containing Noncoded Amino Acids, Peptide Mimetics and Peptide Conjugates

  摘要：

  The ability of the serine protease subtilisin BPN' to catalyze peptide bond formation between fragments containing noncoded amino acids, peptide mimetics, and peptide conjugates in a kinetic approach was explored. It was found that the enzyme accepts numerous of these types of compounds both as acyl donor and acyl acceptor. The results together with specificity studies reported by others provide an active site model as a guideline in the design of enzymatic synthesis of biologically important compounds.

  DOI：

  10.1021/ja964399w
• 作为产物：
  描述：

  肼基甲酸苄酯 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 6-氯-1-羟基苯并三氮唑 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (Cbz-肼基)三氟乙酸甘氨酸酯
  参考文献：
  名称：

  Chelate oxorhenium to assemble new integrin antagonists

  摘要：

  Assembly of independent chemical modules through oxorhenium coordination by a NS2 + S chelation motif was applied to the synthesis of RGD (Arg-Gly-Asp) analogs. Modules were assembled through oxorhenium chelation to give a series of 18 metal complexes in good yields and satisfactory purities. Screening of these oxorhenium coordinates as antagonists of integrins alpha V beta 3, alpha IIb beta 3 and alpha V beta 5 led to the identification of 3 bioactive compounds that exhibit submicromolar affinities for the 3 integrins. Preliminary studies showed that the corresponding oxotechnetium complexes are stable in mice plasma and therefore could be proposed for the molecular imaging of pathologies that overexpress integrins alpha V beta 3 and alpha V beta 5. (C) 2011 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2011.03.008

文献信息

• Polypeptides. LI. Application of S-ethylcarbamoylcysteine to the synthesis of a protected heptatetracontapeptide related to the primary sequence of ribonuclease T1
  作者：Harold T. Storey、John Beacham、Stanley F. Cernosek、Frances M. Finn、Chizuko Yanaihara、Klaus Hofmann

  DOI：10.1021/ja00772a040

  日期：1972.8
• The synthesis of secretin. III. The fragment-condensation approach
  作者：Miguel A. Ondetti、V. L. Narayanan、Malcolm Von Saltza、John T. Sheehan、Emily F. Sabo、Miklos Bodanszky

  DOI：10.1021/ja01019a037

  日期：1968.8