(2S,3S)-4-[4-(benzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]-2,3-dimethylmorpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (2S,3S)-4-[4-(benzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]-2,3-dimethylmorpholine
• 化学式: C₂₀H₂₅N₇O₂
• 分子量: 395.5
• InChiKey: MUHMAIJBIHYGOQ-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT
  申请人：Haruta Kazuhiko

  公开号：US20080113987A1

  公开（公告）日：2008-05-15

  A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

  本发明涉及一种治疗免疫性疾病的哺乳动物的免疫抑制新方法，包括向哺乳动物施用一种由通式（I）表示的杂环化合物的治疗有效量或其药学上可接受的盐。其中X或其他变量的定义见说明书。本发明还涉及一种由通式（II）表示的新型杂环化合物或其药学上可接受的盐。
• HETEROCYCLIC COMPOUNDS AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：ZENYAKU KOGYO KABUSHIKI KAISHA

  公开号：EP1020462A1

  公开（公告）日：2000-07-19

  Heterocyclic compounds in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine and which are represented by the Formula I or phermaceutically acceptable acid addition salts thereof: wherein X and Y respectively represent nitrogen atom or one of them represents nitrogen atom and the other represents C-R7 wherein R7 represents hydrogen or halogen atom; R1, R2, R4, R5 and R6 represent hydrogen atom or C1-C6 alkyl; R3 represents morpholino, piperidino, piperazinyl, thiomorpholino, benzimidazolyl, cyano or the like.

  s-三嗪或嘧啶被苯并咪唑和吗啉取代的杂环化合物，它们由式 I 或其两性可接受的酸加成盐表示： 其中 X 和 Y 分别代表氮原子，或其中一个代表氮原子，另一个代表 C-R7，其中 R7 代表氢原子或卤素原子；R1、R2、R4、R5 和 R6 代表氢原子或 C1-C6 烷基；R3 代表吗啉基、哌啶基、哌嗪基、硫代吗啉基、苯并咪唑基、氰基或类似物。
• IMMUNOSUPPRESSIVE AGENT COMPRISING A HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT
  申请人：ZENYAKU KOGYO KABUSHIKIKAISHA

  公开号：EP1864665B1

  公开（公告）日：2012-05-16
• US6251900B1
  申请人：——

  公开号：US6251900B1

  公开（公告）日：2001-06-26
• US7750001B2
  申请人：——

  公开号：US7750001B2

  公开（公告）日：2010-07-06