(E)-N-异丙基-1-(3-硝基苯基)甲亚胺 | 27895-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (E)-N-异丙基-1-(3-硝基苯基)甲亚胺
• 英文名称: N-isopropyl-m-nitrobenzalimine
• 英文别名: N-(3-nitrobenzylidene)propan-2-amine；2-Propanamine, N-[(3-nitrophenyl)methylene]-；1-(3-nitrophenyl)-N-propan-2-ylmethanimine
• CAS: 27895-80-3
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: HDFNAXYTYVHKHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  (E)-N-异丙基-1-(3-硝基苯基)甲亚胺 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 N-[(3-硝基苯基)甲基]丙-2-胺
  参考文献：
  名称：

  Reactions of N-(chlorobenzyl)alkylamines with sodium methoxide in methanol. Steric effects in elimination reactions

  摘要：

  DOI：

  10.1021/jo00230a018
• 作为产物：
  描述：

  N-chloro-N-[(3-nitrophenyl)methyl]propan-2-amine 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 (E)-N-异丙基-1-(3-硝基苯基)甲亚胺
  参考文献：
  名称：

  Reactions of N-(chlorobenzyl)alkylamines with sodium methoxide in methanol. Steric effects in elimination reactions

  摘要：

  DOI：

  10.1021/jo00230a018

文献信息

• Thiazolidinones Derived from Dynamic Systemic Resolution of Complex Reversible-Reaction Networks
  作者：Yan Zhang、Olof Ramström

  DOI：10.1002/chem.201304690

  日期：2014.3.17

  A complex dynamic system based on a network of multiple reversible reactions has been established. The network was applied to a dynamic systemic resolution protocol based on kinetically controlled lipase‐catalyzed transformations. This resulted in the formation of cyclized products, where two thiazolidinone compounds were efficiently produced from a range of potential transformations.

  建立了一个基于多个可逆反应网络的复杂动态系统。该网络应用于基于动力学控制的脂肪酶催化转化的动态系统分辨率协议。这导致环化产物的形成，其中从一系列潜在的转化中有效地产生了两种噻唑烷酮化合物。
• Benzylamines: synthesis and evaluation of antimycobacterial properties
  作者：Wolfgang R. Meindl、Erwin Von Angerer、Helmut Schoenenberger、Gotthard Ruckdeschel

  DOI：10.1021/jm00375a005

  日期：1984.9

  The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 micrograms/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combinations of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.
• Reactions of N-chloro-N-alkylbenzylamines with amines in acetonitrile. Origin of steric effect in imine-forming elimination
  作者：Bong Rae Cho、Young Wook Suh

  DOI：10.1021/jo00273a016

  日期：1989.6
• ——
  作者：A. A. Sobanov、A. V. Zolotukhin、V. I. Galkin、R. A. Cherkasov、A. N. Pudovik

  DOI：10.1023/a:1020794530963

  日期：——

  For a series of phenyl-substituted N-isopropylbenzalimines, the effect of substituent on their capability to add dimethyl hydrogen phosphite was studied qualitatively in the condensed phase (DTA) and quantitatively (with determination of the kinetic and activation parameters) in 2-propanol solutions with spectrophotometric monitoring of the reaction. A reaction mechanism was proposed, involving formation of a highly organized four-membered transition state.
• Pigin; Groshev; Krasnov, Russian Journal of Organic Chemistry, 1996, vol. 32, # 6, p. 835 - 837
  作者：Pigin、Groshev、Krasnov

  DOI：——

  日期：——