(NZ)-N-(1,4-二苯基亚丁基)羟胺 | 7478-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (NZ)-N-(1,4-二苯基亚丁基)羟胺
• 英文名称: 1,4-diphenyl-butan-1-one oxime
• 英文别名: 1,4-Diphenyl-butan-1-on-oxim；1,4-diphenyl-1-butanone oxime；(NZ)-N-(1,4-diphenylbutylidene)hydroxylamine
• CAS: 7478-61-7
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: MDFHNRQLQFQOTQ-MSUUIHNZSA-N

物化性质

• 熔点：
  102-103 °C
• 沸点：
  401.1±24.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (NZ)-N-(1,4-二苯基亚丁基)羟胺 在 乙醇 、 sodium 作用下， 生成 1,4-diphenylbutan-1-amine
  参考文献：
  名称：

  Ogata; Niinobu, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1942, vol. 62, p. 152,153,158;dtsch.Ref.S.47

  摘要：

  DOI：
• 作为产物：
  描述：

  3-phenylpropyl-magnesium bromide 在 乙醚 作用下， 生成 (NZ)-N-(1,4-二苯基亚丁基)羟胺
  参考文献：
  名称：

  Ogata; Niinobu, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1942, vol. 62, p. 152,153,158;dtsch.Ref.S.47

  摘要：

  DOI：

文献信息

• Diphenylalkanoether and diphenylalkanone oximeether derivatives
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04388469A1

  公开（公告）日：1983-06-14

  Diphenylalkanoether and diphenylalkanone oxime-ether derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro, cyano, di(C.sub.1 -C.sub.4)alkylamino, amino, benzyloxy, hydroxyl, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkanoylamino, C.sub.1 -C.sub.4 alkylamino and N-(C.sub.1 -C.sub.4)alkyl-N-(C.sub.1 -C.sub.4)alkanoylamino, Z.sup.1 is a group of the formula: ##STR2## (wherein R.sup.3 and R.sup.4 are each independently a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an ar(C.sub.1 -C.sub.4)alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a nitrogen-containing 5 to 7-membered saturated heterocyclic group optionally having an oxygen atom or an additional nitrogen atom as the hetero atom in addition to the said nitrogen atom and, in case of having the additional nitrogen atom, bearing a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, an ar(C.sub.1 -C.sub.4)alkyl group or a phenyl group thereon), ##STR3## is a group of the formula: ##STR4## or the formula: ##STR5## A.sup.1 is a C.sub.2 -C.sub.6 alkylene group and A.sup.2 is a C.sub.2 -C.sub.4 alkylene group, and non-toxic, pharmaceutically acceptable acid addition salts thereof, which have cerebral vasodilating activity and antihypoxic activity.

  二苯基烷氧基和二苯基酮肟-醚衍生物的化学式为：##STR1## 其中，R.sup.1和R.sup.2各自独立地为芳基基团，可选地取代有1至3个来自卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、硝基、氰基、二(C.sub.1-C.sub.4)烷基氨基、氨基、苄氧基、羟基、C.sub.1-C.sub.4烷硫基、C.sub.1-C.sub.4烷基亚硫酰基、C.sub.1-C.sub.4烷基磺酰基、C.sub.1-C.sub.4烷基酰胺基、C.sub.1-C.sub.4烷基氨基和N-(C.sub.1-C.sub.4)烷基-N-(C.sub.1-C.sub.4)烷基酰胺基的取代基；Z.sup.1为下式的基团：##STR2##（其中，R.sup.3和R.sup.4各自独立地为氢原子、C.sub.1-C.sub.4烷基或ar(C.sub.1-C.sub.4)烷基或与相邻的氮原子结合时，代表一个含氮5至7元饱和杂环基团，该基团可选地具有一个氧原子或一个额外的氮原子作为杂原子，此外还有所述氮原子，并且在具有额外的氮原子的情况下，在其上具有一个氢原子、C.sub.1-C.sub.4烷基、ar(C.sub.1-C.sub.4)烷基或苯基）；##STR3## 为下式的基团：##STR4## 或下式的基团：##STR5## A.sup.1为C.sub.2-C.sub.6烷基，A.sup.2为C.sub.2-C.sub.4烷基，以及其无毒、药学上可接受的酸盐，具有脑血管扩张活性和抗缺氧活性。
• Copper‐Catalyzed Aza‐Sonogashira Cross‐Coupling To Form Ynimines: Development and Application to the Synthesis of Heterocycles
  作者：Rémi Lavernhe、Rubén O. Torres‐Ochoa、Qian Wang、Jieping Zhu

  DOI：10.1002/anie.202110901

  日期：2021.11.2

  AbstractNitrogen‐substituted alkynes, such as ynamines and ynamides, are versatile synthetic building blocks. Ynimines bearing additional nucleophilic and electrophilic centers relative to ynamines and ynamides are expected to have high synthetic potential. However, their chemical reactivity remains unexplored owing mainly to the lack of synthetic accessibility. We report herein a versatile copper‐catalyzed synthesis of ynimines from readily available O‐acetyl ketoximes and terminal alkynes. A wide range of O‐acetyl ketoximes derived from diaryl ketones, aryl alkyl ketones and dialkyl ketones underwent cross‐coupling with a diverse set of terminal alkynes to afford the ynimines in good to excellent yields. An unprecedented [5+1] heteroannulation reaction exploiting the reactivity of the ynimine generated in situ was subsequently developed for the synthesis of medicinally important heterocycles, including isoquinolines, azaindoles, azabenzofurans, azabenzothiophenes and carbolines.
• Diphenylalkanoether and diphenylalkanone oximeether derivatives, a process for their production, pharmaceutical compositions and their use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0017217B1

  公开（公告）日：1985-03-13
• US4388469A
  申请人：——

  公开号：US4388469A

  公开（公告）日：1983-06-14
• US4426394A
  申请人：——

  公开号：US4426394A

  公开（公告）日：1984-01-17