(3-Methyl-2-oxochromen-7-yl) dihydrogen phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (3-Methyl-2-oxochromen-7-yl) dihydrogen phosphate
• 化学式: C₁₀H₉O₆P
• 分子量: 256.15
• InChiKey: YOTOVKOKSVLXSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS THAT INHIBIT NF?B ACTIVITY<br/>[FR] COMPOSÉS INHIBANT L'ACTIVITÉ DE NF?B
  申请人：UNIV COLUMBIA

  公开号：WO2010051064A1

  公开（公告）日：2010-05-06

  The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.

  本发明涉及具有BACE1和NFκB调节活性的化合物，以及治疗、预防或改善神经退行性疾病（如阿尔茨海默病）的方法。本发明还涉及使用这些化合物或含有这些候选化合物的药物组合物治疗与细胞增殖、免疫系统和/或炎症功能失调相关的疾病。
• Fluorochromes for organelle tracing and multi-color imaging
  申请人：Patton Wayne Forrest

  公开号：US20100062429A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和试剂盒，用于鉴定感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，用于确定细胞器的位置、数量，甚至用于区分感兴趣的细胞中的细胞器。
• Novel fluorochromes for organelle tracing and multi-color imaging
  申请人：Pande Praveen

  公开号：US20100062460A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和工具包，用于识别感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，以识别感兴趣细胞中细胞器的位置、位置或数量，甚至用于区分细胞器。
• BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
  申请人：CRINE Philippe

  公开号：US20100221234A1

  公开（公告）日：2010-09-02

  A bone delivery conjugate having a structure selected from the group consisting of: A) X-D n -Y-protein-Z; and B) Z-protein-Y-D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.

  一种骨骼传递共轭物，其结构选自以下组合：A）X-Dn-Y-蛋白质-Z；和B）Z-蛋白质-Y-Dn-X，其中X不存在或是至少一个氨基酸序列，Y不存在或是至少一个氨基酸序列，Z不存在或是至少一个氨基酸序列，而Dn是一种聚天冬氨酸，其中n = 10至16。包含该物质的组合物以及使用方法。
• METHODS AND COMPOSITIONS FOR ENZYME LINKED IMMUNO AND HYBRIDIZATION MASS SPECTROMETRIC ASSAY
  申请人：YYZ Pharmatech, Inc.

  公开号：US20160223530A1

  公开（公告）日：2016-08-04

  Disclosed are sensitive methods for detecting a target substance in low concentrations. The method can include immobilizing a target substance to a solid phase; incubating the immobilized target substance with a reporter enzyme detection probe in solution under conditions for forming target: enzyme detection probe complexes; washing the solid phase to remove any unbound reporter enzyme detection probe; incubating the target: enzyme detection probe complex with a reporter enzyme detection probe substrate in substrate reaction solution to generate one or more ionizable products; and detecting one or more of the one or more ionizable products using mass spectrometry (MS).

  本发明涉及一种敏感的低浓度目标物检测方法。该方法可以包括将目标物质固定到固相上；在形成目标物：酶检测探针复合物的条件下，将固定的目标物质与溶液中的报告酶检测探针孵育；洗涤固相以去除任何未结合的报告酶检测探针；将目标物：酶检测探针复合物与报告酶检测探针底物在底物反应溶液中孵育，以产生一个或多个可离子化产物；并使用质谱（MS）检测一个或多个可离子化产物中的一个或多个。