1-acetoxy-4-(1-chloro-2-methylamino-ethyl)-benzene | 136529-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 1-acetoxy-4-(1-chloro-2-methylamino-ethyl)-benzene
• 英文别名: 1-Acetoxy-4-(1-chlor-2-methylamino-aethyl)-benzol；4-(1-Chloro-2-(methylamino)ethyl)phenyl acetate；[4-[1-chloro-2-(methylamino)ethyl]phenyl] acetate
• CAS: 136529-69-6
• 化学式: C₁₁H₁₄ClNO₂
• 分子量: 227.691
• InChiKey: VZCQEZNQVVYTJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 溶剂黄146 作用下， 生成 1-acetoxy-4-(1-chloro-2-methylamino-ethyl)-benzene
  参考文献：
  名称：

  �ber verschiedene Reaktionen an Phenylalkanolaminen und Phenylalkanonaminen

  摘要：

  DOI：

  10.1007/bf00942492

文献信息

• Substituted phenyl aziridine precursor analogs for inhibiting androgen-independent prostate cancer cell growth
  申请人：Northwestern University

  公开号：US10799475B2

  公开（公告）日：2020-10-13

  Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

  公开了调节一种或多种类固醇受体活性的方法和药物组合物。这些方法和药物组合物通常包括一种或多种取代苯基氮丙啶前体、各自的氮丙啶、其类似物、其衍生物或其药学上可接受的盐，如 CpdA。这些方法和组合物可用于治疗与糖皮质激素受体活性、雄激素受体活性或两者相关的疾病、失调和病症，如癌症、寻常痤疮和脱发。
• USE OF CARBOXY COMPOUNDS SUCH AS 2(4-ACETOXYPHENYL)-2-CHLORO-N-METHYL-ETHYLAMMONIUM CHLORIDE AS ANTI-INFLAMMATORY AGENTS
  申请人：Vlaams Interuniversitair Instituut voor Biotechnologie vzw.

  公开号：EP1239850A1

  公开（公告）日：2002-09-18
• Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities
  申请人：Budunova Irina

  公开号：US20090156672A1

  公开（公告）日：2009-06-18

  Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.
• METHOD FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF GLUCOCORTICOID-INDUCED OSTEOPOROSIS
  申请人：Fritz-Lipmann-Institut E. V. Leibniz-Institut Fuer

  公开号：US20130171097A1

  公开（公告）日：2013-07-04

  The present invention relates to a method for the prophylactic and/or therapeutic treatment of glucocorticoid induced osteoporosis comprising maintaining or restoring AP-1 activity or AP-1-mediated effects, for example by LIF treatment. The method may additionally comprise a method for the treatment of a medical condition associated with inflammation comprising inhibition of NF-KB activity, for example by glucocorticoid (GC) treatment. The present invention therefore also relates to a method for the treatment and/or prevention of glucocorticoid induced osteoporosis comprising the administration of an effective amount of LIF to a subject, preferably in combination with GC treatment.
• Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth
  申请人：Northwestern University

  公开号：US20140045938A1

  公开（公告）日：2014-02-13

  Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.