N-[4-(trifluoromethyl)phenyl]-2-[5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxyphenyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(trifluoromethyl)phenyl]-2-[5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxyphenyl]acetamide
• 英文别名: N-[4-(Trifloromethyl)phenyl]-2-[5-[(2,4-dioxothiazolidin-5-yl)methyl]2-methoxyphenyl]acetamide；2-[5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxyphenyl]-N-[4-(trifluoromethyl)phenyl]acetamide
• 化学式: C₂₀H₁₇F₃N₂O₄S
• 分子量: 438.427
• InChiKey: NWHZKXRTSZQRAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-[4-(Trifluoromethyl)phenyl]-2-[5-[(2,4-dioxothiazolidin-5-ylidene)methyl]-2-methoxyphenyl]acetamide 在 钯 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 以172mg (57%)的产率得到N-[4-(trifluoromethyl)phenyl]-2-[5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxyphenyl]acetamide
  参考文献：
  名称：

  SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES

  摘要：

  公开号：

  EP1213287B1

文献信息

• Substituted benzylthiazolidine-2, 4-dione derivatives
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：US06730687B1

  公开（公告）日：2004-05-04

  The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives that bind to receptor to activate as ligands of human peroxisome proliferator-activated receptor (PPAR) and exhibit blood glucose-decreasing action and lipid-decreasing action, and processes for preparing them. It relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein the bond mode of A denotes —CH2CONH—, —NHCONH—, —CH2CH2CO— or —NHCOCH2—, and B denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, halogen atom, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and processes for preparing them.

  该发明提供了新型的取代苯基噻唑烷-2,4-二酮衍生物，其结合受体以激活人类过氧化物酶体增殖物激活受体（PPAR）作为配体，并表现出降低血糖和降低脂质的作用，以及制备它们的过程。它涉及由通式（1）所表示的取代苯基噻唑烷-2,4-二酮衍生物 [其中，A的键合模式表示为—CH2CONH—、—NHCONH—、—CH2CH2CO—或—NHCOCH2—，B表示碳原子为1到4的低碳基，碳原子为1到3的低碳氧基，卤素原子，三氟甲基基团，三氟甲氧基团，苯基未取代或可能有取代基，苯氧基未取代或可能有取代基或苄氧基未取代或可能有取代基]，其医学上可接受的盐，其水合物和制备它们的过程。
• US6730687B1
  申请人：——

  公开号：US6730687B1

  公开（公告）日：2004-05-04