2-[2-pyridylmethylsulfinyl]-(5-hydroxy)benzimidazole | 81729-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[2-pyridylmethylsulfinyl]-(5-hydroxy)benzimidazole
• 英文别名: 2-(pyridin-2-ylmethylsulfinyl)-3H-benzimidazol-5-ol
• CAS: 81729-17-1
• 化学式: C₁₃H₁₁N₃O₂S
• 分子量: 273.315
• InChiKey: GJMRPDDGLFEJAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  98.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Benzimidazoles and their pharmaceutical use
  申请人：THE UPJOHN COMPANY

  公开号：EP0045200A1

  公开（公告）日：1982-02-03

  Substituted alkylsulfinylbenzimidazoles for use as pharmaceuticals or as active ingredients in pharmaceutical compositions, especially of the formula wherein R1, R2, R3 and -X1-Het are defined as given in the description. The compounds are used in the treatment or prevention of special gastrointestinal inflammatory diseases.

  用作药物或药物组合物活性成分的取代烷基亚磺酰基苯并咪唑，特别是以下式子 其中 R1、R2、R3 和 -X1-Het 的定义如描述中所给。这些化合物可用于治疗或预防特殊的胃肠道炎症疾病。
• INHIBITORS OF H+K+ -ATPASE
  申请人：Advanced Medicine, Inc.

  公开号：EP1143991A2

  公开（公告）日：2001-10-17
• METHOD OF TREATING SNORING AND OTHER OBSTRUCTIVE BREATHING DISORDERS
  申请人：Flores Rosas, David

  公开号：EP1572098A2

  公开（公告）日：2005-09-14
• COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS
  申请人：Atopix Therapeutics Limited

  公开号：EP2790696A1

  公开（公告）日：2014-10-22
• Method of treating snoring and other obstructive breathing disorders
  申请人：——

  公开号：US20040258621A1

  公开（公告）日：2004-12-23

  A method of pharmaceutically managing snoring and impaired breathing is provided. This invention relates to treating snoring, sleep apnea, and other forms of sleep-disordered breathing in those with or without symptoms of or the diagnosis of gastro-intestinal reflux disease (GERD). It comprises administration of a therapeutically effective dose of Prevacid (Lansoprazole) or any other medication that can be used to treat symptoms of hyper-acidity or gastrointestinal reflux disease (GERD). The therapeutic medication may be used alone or in combination with other pharmacologic agents or mechanical modalities including but not limited to decongestants, antihistamines or mechanical nasal toilet. It also is of benefit in improving breathing disorders that are present while awake.