1-Cyclohex-3-enylmethyl-3-(2-hydroxy-ethyl)-thiourea

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 英文名称: 1-Cyclohex-3-enylmethyl-3-(2-hydroxy-ethyl)-thiourea
• 英文别名: 1-(Cyclohex-3-en-1-ylmethyl)-3-(2-hydroxyethyl)thiourea
• 化学式: C₁₀H₁₈N₂OS
• 分子量: 214.332
• InChiKey: AIAMIUXOCINCPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• (2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors
  申请人：ALLERGAN SALES, INC.

  公开号：US20020161051A1

  公开（公告）日：2002-10-31

  Compounds of formula (i) and of formula (ii) 1 wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate &agr; 2B and/or &agr; 2C adrenergic receptors in preference over &agr; 2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.

  式（i）和式（ii）的化合物 其中符号的含义在说明书中披露，特别或选择性地调节&agr; 2B 和/或&agr; 2C 肾上腺素受体，优先于&agr; 2A 肾上腺素受体，因此对缓解慢性疼痛和触痛有用，并且几乎没有或只有极小的心血管和/或镇静活性。
• (2-HYDROXY)ETHYL-THIOUREAS USEFUL AS MODULATORS OF ALPHA2B ADRENERGIC RECEPTORS
  申请人：Allergan, Inc.

  公开号：EP1381593A2

  公开（公告）日：2004-01-21
• US6534542B2
  申请人：——

  公开号：US6534542B2

  公开（公告）日：2003-03-18
• [EN] (2-HYDROXY)ETHYL-THIOUREAS USEFUL AS MODULATORS OF ALPHA2B ADRENERGIC RECEPTORS<br/>[FR] (2-HYDROXY)ETHYLTHIOUREAS UTILES EN TANT QUE MODULATEURS DES RECEPTEURS ADRENERGIQUES ALPHA2B
  申请人：ALLERGAN INC

  公开号：WO2002068384A2

  公开（公告）日：2002-09-06

  Compounds of formula (i) and of formula (ii), wherein the symbols have the meaning disclosed in the claims, specifically or selectively modulate α2A adrenergic receptors and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardiovascular and/or sedatory activity. The invention also relates to a method of activating α2B or α2C adrenergic receptors in a mammal by administering a compound that has α2Bor α2C adrenergic receptor activity and has no significant α2A agonist activity.