7-(2,4-dichlorophenyl)-3-(1-ethoxyethyl)-2-ethyl-pyrazolo[1,5-a]pyrimidine | 1027446-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-(2,4-dichlorophenyl)-3-(1-ethoxyethyl)-2-ethyl-pyrazolo[1,5-a]pyrimidine
• 英文别名: 7-(2,4-Dichlorophenyl)-3-(1-ethoxyethyl)-2-ethylpyrazolo[1,5-a]pyrimidine
• CAS: 1027446-58-7
• 化学式: C₁₈H₁₉Cl₂N₃O
• 分子量: 364.274
• InChiKey: JAAHKBAXIIDEIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pyrazolopyrimidines as CRF antagonists
  申请人：——

  公开号：US20030139426A1

  公开（公告）日：2003-07-24

  The present invention relates to pyrazolopyrimidines according to formula (I) 1 and stereoisomers, isomers and salts thereof wherein R 1 -R 5 are selected from certain alkyl, aryl and heteroaryl species as defined in the specification wherein all of the compounds are useful as CRF antagonists and are thus useful in the treatment of neurological disorders as well as a multitude of other CRF associated diseases or conditions.

  本发明涉及式(I)1的吡唑吡嘧啶及其立体异构体、异构体和盐，其中R1-R5从特定的烷基、芳基和杂环芳基物种中选择，如规范中所定义，其中所有化合物均可用作CRF拮抗剂，因此可用于治疗神经系统疾病以及多种其他与CRF相关的疾病或症状。
• US6958341B2
  申请人：——

  公开号：US6958341B2

  公开（公告）日：2005-10-25
• [EN] PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS<br/>[FR] PYRAZOLOPYRIMIDINES ANTAGONISTES DE CORTICOLIBERINE (CRF)
  申请人：DU PONT PHARM CO

  公开号：WO2000059908A2

  公开（公告）日：2000-10-12

  The present invention relates to pyrazolopyrimidines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species as defined in the specification wherein all of the compounds are useful as CRF antagonists and are thus useful in the treatment of neurological disorders as well as a multitude of other CRF associated diseases or conditions.