1-N-(3-methylbutyl)-1-N'-(5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl)cyclopentane-1,1-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 1-N-(3-methylbutyl)-1-N'-(5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl)cyclopentane-1,1-dicarboxamide
• 化学式: C₂₇H₃₃N₃O₃
• 分子量: 447.6
• InChiKey: SGTINZHTECZGOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• CYCLIC MALONAMIDES AS INHIBITORS OF ABETA PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20100009965A1

  公开（公告）日：2010-01-14

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式（I）的新型环状马隆酰胺，其药物组成物和使用方法。这些新化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ-肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经疾病，如阿尔茨海默病和唐氏综合症。
• CYCLIC MALONAMIDES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20090264419A1

  公开（公告）日：2009-10-22

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有以下公式（I）的新型环状马隆酰胺、其制药组合物以及使用方法。这些新化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ-肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及与β-淀粉样蛋白产生有关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。
• CYCLIC MALONAMIDES AS INHIBITORS OF ASS PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20080275024A1

  公开（公告）日：2008-11-06

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有以下式子（I）的新型环状马隆酰胺，其药物组成和使用方法。这些新化合物抑制淀粉样前体蛋白的处理，更具体地抑制Aβ肽的产生，从而防止神经沉积物的淀粉样蛋白的形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。
• CYCLIC MALONAMIDES AS INHIBITORS OF A BETA PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20100041639A1

  公开（公告）日：2010-02-18

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式（I）的新型环状马隆酰胺，其药物组成和使用方法。这些新的化合物抑制淀粉样前体蛋白的处理，更具体地抑制Aβ肽的产生，从而防止神经沉积物的淀粉样蛋白的形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，如阿尔茨海默病和唐氏综合症。
• US7276496B2
  申请人：——

  公开号：US7276496B2

  公开（公告）日：2007-10-02