(S)-3-苄氧基吡咯烷盐酸盐 | 931409-74-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (S)-3-苄氧基吡咯烷盐酸盐
• 英文名称: (S)-3-benzyloxypyrrolidine hydrochloride
• 英文别名: (3S)-3-(benzyloxy)pyrrolidine hydrochloride；(s)-3-Benzyloxy-pyrrolidine hydrochloride；(3S)-3-phenylmethoxypyrrolidine;hydrochloride
• CAS: 931409-74-4
• 化学式: C₁₁H₁₅NO*ClH
• 分子量: 213.707
• InChiKey: HIPRPABXTKKPPY-MERQFXBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  (S)-3-苄氧基吡咯烷盐酸盐 、 ethyl 5-bromo-2-[methyl(5-methyl-6-{[(2Z)-3-{[2-(trimethylsilyl)ethoxy]methyl}-2,3-dihydro-1,3-benzothiazol-2-ylidene]amino}pyridazin-3-yl)amino]-1,3-thiazole-4-carboxylate 在 rac-BINAP Pd G₃ 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以49%的产率得到ethyl 5-[(3S)-3-(benzyloxy)pyrrolidin-1-yl]-2-[methyl(5-methyl-6-{[(2Z)-3-{[2-(trimethylsilyl)ethoxy]methyl}-2,3-dihydro-1,3-benzothiazol-2-ylidene]amino}pyridazin-3-yl)amino]-1,3-thiazole-4-carboxylate
  参考文献：
  名称：

  WO2021018857A5

  摘要：

  公开号：

  WO2021018857A5

文献信息

• Carboxamide derivatives as muscarinic receptor antagonists
  申请人：Glossop Alan Paul

  公开号：US20070105831A1

  公开（公告）日：2007-05-10

  The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

  本发明涉及具有下列公式的化合物、其制备方法和中间体，以及包含它们的抗胆碱能药物组合物。
• Carboxamide Derivatives As Muscarinic Receptor Antagonists
  申请人：Glossop Paul Alan

  公开号：US20100029720A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

  本发明涉及具有以下式的化合物，以及制备它们的过程和中间体，它们作为毒蕈碱受体拮抗剂的用途和包含它们的制药组合物。
• Process for Production of Benzyloxypyrrolidine Derivative, and Process for Production of Hydrochloride Salt Powder of Optically Active Benzyloxypyrrolidine Derivative
  申请人：Morimoto Masao

  公开号：US20090093643A1

  公开（公告）日：2009-04-09

  Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrrolidine derivative expressed by the general formula (2) [Chemical formula 2], in reacting a pyrrolidinol derivative represented by the general formula (1) [Chemical formula 1] with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is carried out in either of the following conditions A or B; condition A: an aprotic polar solvent, and condition B: an aliphatic ether solvent containing a phase transfer catalyst:

  提供了一种高产率和安全性的苯甲氧吡咯烷衍生物的生产工艺，以及一种高产率和安全性的苯甲氧吡咯烷衍生物盐酸盐粉末的生产工艺。苯甲氧吡咯烷衍生物的生产工艺由化学式（2）[化学式2]表示，通过在碱金属氢氧化物存在下，用苯甲醇衍生物与苯甲基卤代物反应，反应条件为以下条件A或B之一：条件A为无极性极性溶剂，条件B为含有相转移催化剂的脂肪醚溶剂。
• PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE
  申请人：Kaneka Corporation

  公开号：EP1947083A1

  公开（公告）日：2008-07-23

  The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.

  本发明提供了一种生产 3-烷氧基吡咯烷衍生物的工艺，这种衍生物对医药产品等的生 产非常重要。在本发明中，通过让芳基卤化物在碱和金属卤化物及相转移催化剂中的至少一种存在下起作用，将 N-保护-3-羟基吡咯烷转化为 N-保护-3-芳烷氧基吡咯烷，然后去保护 N-保护基团，将其转化为 3-芳烷氧基吡咯烷衍生物，随后在含有极性溶剂的溶剂中处理该衍生物、从而得到晶体状的 3-烷氧基吡咯烷衍生物。根据本发明，可以方便、高效地在工业规模上生产出高纯度的 3-芳基氧基吡咯烷衍生物。
• PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：EP1950198B1

  公开（公告）日：2014-08-06