3-amino-6-(4-chlorophenyl)-5-methyl-N-pyridin-3-ylpyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-amino-6-(4-chlorophenyl)-5-methyl-N-pyridin-3-ylpyrazine-2-carboxamide
• 化学式: C₁₇H₁₄ClN₅O
• 分子量: 339.8
• InChiKey: OUINJBWHJKOQHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Heterocyclic amines for the treatment of conditions associated with gsk-3
  申请人：——

  公开号：US20040186113A1

  公开（公告）日：2004-09-23

  The present invention relates to new compounds of the formula (I) wherein Y, X, P, Q, R 1 , R 2 , R 3 , R 4 , R 5A , R 6 , R 7 , R 8 , R 9 , A, B, n, m are defined as in claim 1, a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds for the treatment of conditions associated with glycogen synthase kinase-3 (GSK3) as well as an intermediate used in the preparation of said compounds. 1

  本发明涉及公式（I）的新化合物，其中Y，X，P，Q，R1，R2，R3，R4，R5A，R6，R7，R8，R9，A，B，n，m的定义如权利要求书中所述，以及其制备过程，含有所述治疗活性化合物的制药配方以及所述活性化合物用于治疗与糖原合成酶激酶-3（GSK3）相关的疾病的用途，以及用于制备所述化合物的中间体。
• HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3
  申请人：AstraZeneca AB

  公开号：EP1406877A1

  公开（公告）日：2004-04-14
• [EN] HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3<br/>[FR] AMINES HETEROCYCLIQUES POUR LE TRAITEMENT DE PATHOLOGIE EN RAPPORT AVEC GSK-3
  申请人：ASTRAZENECA AB

  公开号：WO2003004475A1

  公开（公告）日：2003-01-16

  The present invention relates to new compounds of the formula (I) wherein Y, X, P, Q, R1, R2, R3, R4, R5, R6, R7, R8, R9, A, B, n, m are defined as in claim 1, a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds for the treatment of conditions associated with glycogen synthase kinase-3 (GSK3) as well as an intermediate used in the preparation of said compounds.