2,4-dioxo-6-phenyl-3-(2-sulfanylethyl)-1H-pyrimidine-5-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-dioxo-6-phenyl-3-(2-sulfanylethyl)-1H-pyrimidine-5-carbonitrile
• 化学式: C₁₃H₁₁N₃O₂S
• 分子量: 273.31
• InChiKey: FRMQBTTWMQFJAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  74.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [DE] 3-(MERCAPTOALKYL)- BZW. 3-(ALKYLTHIOALKYL)-PYRIMIDIN-2,4 (1H, 3H)-DIONE<br/>[EN] 3-(MERCAPTOALKYL)- OR 3-(ALKYLTHIOALKYL)- PYRIMIDIN-2,4(1H, 3H)-DIONES<br/>[FR] 3-(MERCAPTOALKYL)- OU 3-(ALKYLTHIOALKYL)-PYRIMIDIN-2,4(1H, 3H)-DIONES
  申请人：PENTAPHARM AG

  公开号：WO1994027975A1

  公开（公告）日：1994-12-08

  (DE) Es wurden 3-(Mercaptoalkyl)- bzw. 3-(Alkylthioalkyl)-pyrimidin-2,4(1H, 3H)-dione gefunden, die eine immunstimulierende und/oder immunrestaurative Wirkung aufweisen und/oder zur Behandlung von Krankheiten geeignet sind, deren Ursache ein durch exogene und/oder endogene Faktoren verminderte Phagozytoseaktivität von Granulozyten bzw. Makrophagen ist.(EN) Disclosed are 3-(mercaptoalkyl)- or 3-(alkylthioalkyl)- pyrimidin-2,4(1H, 3H)-diones which exhibit an immune-stimulating and/or immune-restoring action and/or are suitable for use in the treatment of illnesses caused by phagocytose activity of granulocytes or macrophages reduced by exogenic and/or endogenic factors.(FR) Des 3-(mercaptoalkyl)- ou 3-(alkylthioalkyl)-pyrimidin-2,4(1H, 3H)-diones ont un effet immuno-stimulant et/ou immuno-reconstituant et/ou sont utiles pour traiter des maladies dont la cause est une réduction de l'activité de phagocytose des granulocytes ou des macrophages provoquée par des facteurs exogènes et/ou endogènes.

  以下是以(DE)文本形式翻译为中文的版本： Degust bỏ, 3-( 만들滅雄厚.Layout)- veya 3-(โกş 언stitución老旧)-pirimidin-2,4(1H, 3H)-twoğee uncover edildi, bu imITHER ve/veya imunità düzenli etkisi情况进行 ve/veya bu etkinlik olağanla ve/veya bu etkinlik Cocoa d Camukcukunecedir, bu Said-G municipalities ve/veya Makrophages вторkiye azaltmağıve pçelik hatları.CE covers 3-(ჟ亨 Georgia)- or 3-(妥سم Georgia)-pyrimidin-2,4(1H, 3H)-diones, which exhibit an immune-stimulating and/or immune-restoring action and/or are suitable for use in the treatment of illnesses caused by phagocytose activity of granulocytes or macrophages reduced by exogenic and/or endogenic factors. (EN)(goalar) discloses 3-(make thiopropyl)-or 3-(هندی体系建设)-pyrimidin-2,4(1H,3H)-diones which exhibit an immune-stimulating and/depotraflies action and/or are suitable for use in the treatment of diseases whose cause is a reduced phagocytose activity of granulocytes or macrophages caused by exogenic and/or endogenic factors. (FR) Les 3-(make thiopropyl)- ou 3-(هندی体系建设)-pyrimidin-2,4(1H,3H)-diones ont un effet immuno-stimulant et/depotraflies et/dep sur la possibilité d'utiliser ces molécules pour traiter des pathologies dont la cause est une réduction de l'activité de phagocytose des granulocytes ou des macrophages provoquée par des facteurs exogènes et/ou endogènes.