5-phenyl-2-phenylsulfonylpyrazine-3-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-phenyl-2-phenylsulfonylpyrazine-3-carbonitrile
• 英文别名: 3-(Benzenesulfonyl)-6-phenylpyrazine-2-carbonitrile
• 化学式: C₁₇H₁₁N₃O₂S
• 分子量: 321.359
• InChiKey: FFMFKPGYBOCOSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-phenyl-2-phenylthiopyrazine-3-carbonitrile 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到5-phenyl-2-phenylsulfonylpyrazine-3-carbonitrile
  参考文献：
  名称：

  A REGIOSELECTIVE SYNTHESIS OF METHYL 7-AMINO-3-PHENYLTHIENO-[2,3-b]PYRAZINE-6-CARBOXYLATE

  摘要：

  A practical synthesis of methyl 7-amino-3-phenylthieno[2,3-b]pyrazine-6-carboxylate (1) has been achieved via a regioselective synthesis of 3-cyano-5-phenyl-3-phenylthiopyrazine (5a), by condensing 1,1 -diethoxyacetophenone with 2,3-diamino-3-phenylthioacrylonitrile.

  DOI：

  10.1081/scc-100103262

文献信息

• PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS
  申请人：ABBOTT LABORATORIES

  公开号：EP1115710A1

  公开（公告）日：2001-07-18
• [EN] PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS<br/>[FR] PROCEDE DE PREPARATION D'ISOMERES REGIOSPECIFIQUES DE PYRAZINE SUBSTITUEE
  申请人：ABBOTT LAB

  公开号：WO2000010983A1

  公开（公告）日：2000-03-02

  The present invention relates to a process of producing specific isomers of substituted pyrazine compounds, substituted thieno[b]pyrazine, substituted pteridins, compounds, and derivatives thereof. The regiospecific substituted pyrazine compounds are useful in the preparation of pharmaceuticals, including compounds useful in treating benign prostatic hyperplasia.
• A REGIOSELECTIVE SYNTHESIS OF METHYL 7-AMINO-3-PHENYLTHIENO-[2,3-<i>b</i>]PYRAZINE-6-CARBOXYLATE
  作者：Weijiang Zhang、Anthony R. Haight、Kelley L. Ford、Shyamal I. Parekh

  DOI：10.1081/scc-100103262

  日期：2001.1

  A practical synthesis of methyl 7-amino-3-phenylthieno[2,3-b]pyrazine-6-carboxylate (1) has been achieved via a regioselective synthesis of 3-cyano-5-phenyl-3-phenylthiopyrazine (5a), by condensing 1,1 -diethoxyacetophenone with 2,3-diamino-3-phenylthioacrylonitrile.