5,5-dibenzyl-2,3-dihydroimidazo(2,1-b)thiazol-6(5H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5-dibenzyl-2,3-dihydroimidazo(2,1-b)thiazol-6(5H)-one
• 英文别名: 5,5-Dibenzyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-one
• 化学式: C₁₉H₁₈N₂OS
• 分子量: 322.431
• InChiKey: QHPCIEDAPPRFTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  58
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• METHODS FOR TREATING DEPRESSION, NEURODEGENERATION, INHIBITING AMYLOID BETA DEPOSITION, DELAYING SENESCENCE, AND EXTENDING LIFE SPANS WITH HETEROCYCLIC COMPOUNDS
  申请人：Yamaguchi Yoshimasa

  公开号：US20080103157A1

  公开（公告）日：2008-05-01

  Disclosed is an antidepressant, neuroprotectant, amyloid β deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):

  揭示了一种抗抑郁剂、神经保护剂、淀粉样蛋白β沉积抑制剂或延缓衰老的组合物，其中包含具有通用式(I)的杂环化合物。
• METHOD OF TREATING COGNITIVE IMPAIRMENT
  申请人：YAMAGUCHI Yoshimasa

  公开号：US20090221554A1

  公开（公告）日：2009-09-03

  Disclosed is an method of treating cognitive impairment, including administering to a subject in need thereof a combination of a therapeutic agent for neurodegenerative disease and a therapeutically effective amount of a heterocyclic compound represented by the following general formula (I):

  本发明揭示了一种治疗认知障碍的方法，包括向需要治疗的受试者施用一种神经退行性疾病治疗剂和一种由以下一般式(I)表示的杂环化合物的治疗有效量的组合物。
• Method of Treating Cognitive Impairment
  申请人：WEBER Eckard

  公开号：US20100256173A1

  公开（公告）日：2010-10-07

  This invention relates to the treatment and prevention of cognitive impairment, and particularly to the treatment and prevention of cognitive impairment caused by or associated with Huntington's Disease, Lewy Body Dementia, Pick's Disease and Down's Syndrome.

  本发明涉及治疗和预防认知障碍，特别是治疗和预防由亨廷顿病、路易体痴呆、皮克氏病和唐氏综合症引起或相关的认知障碍。
• Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment
  申请人：Green Kim Nicholas

  公开号：US20100168135A1

  公开（公告）日：2010-07-01

  The present invention provides a method of inducing cleavage of amyloid precursor protein to produce an approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein in a subject, the method comprising administering a heterocyclic compound or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof, wherein the approximately 17 kilodalton fragment includes the carboxyterminal amino acid sequence of amyloid precursor protein and amyloid-beta amino acid sequence. Also provided is a screening method for identifying compounds induce cleavage of amyloid precursor protein to produce the approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein.

  本发明提供了一种诱导淀粉样前体蛋白裂解以产生约17千道顿的淀粉样前体蛋白羧基末端片段的方法，其中该方法包括向需要该方法的受体中给予杂环化合物或其药学上可接受的盐、水合物或前药，其中约17千道顿的片段包括淀粉样前体蛋白羧基末端氨基酸序列和淀粉样β氨基酸序列。还提供了一种筛选诱导淀粉样前体蛋白裂解以产生约17千道顿淀粉样前体蛋白羧基末端片段的化合物的方法。
• Neuroprotectant containing heterocyclic compound having specific structure
  申请人：ZENYAKU KOGYO KABUSHIKIKAISHA

  公开号：EP2388000A2

  公开（公告）日：2011-11-23

  Disclosed is a neuroprotectant composition containing a heterocyclic compound having the general formula (1).

  本发明公开了一种神经保护剂组合物，其中含有通式（1）的杂环化合物。