N-[(2R)-1-[formyl(hydroxy)amino]hexan-2-yl]-2-naphthalen-1-ylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(2R)-1-[formyl(hydroxy)amino]hexan-2-yl]-2-naphthalen-1-ylacetamide
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.4
• InChiKey: OAQDZBRRYBBOSZ-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Antimicrobial agents
  申请人：——

  公开号：US20040102491A1

  公开（公告）日：2004-05-27

  Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(═O) or of formula C(═O)NH(OH); R 1 represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(═O), a hydroxy or amino group; R 2 represents a radical of formula R 10 —(X) n -(ALK) m — wherein R 10 represents hydrogen, or an optionally substituted c 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C 1 -C 6 alkylene, C 2 -C 6 ?alkenylene, or C 2 -C 6 alkynylene radical, and may be interrupted by one or more non-adjacent NH—, —O— or S— linkages, X represents NH—, —O— or S—, and m and n are independently 0 or 1; R 3 represents hydrogen, C 1 -C 6 alkyl, or benzyl; and R 4 is as defined in the specification.

  式(I)和(IA)的化合物具有抗菌或抗原虫活性：式(1)式(2)其中：Z代表式N(OH)CH(═O)或式C(═O)NH(OH)的基团；R1代表氢、甲基或三氟甲基，或者除非Z是式N(OH)CH(═O)的基团时，还可以是羟基或氨基；R2代表式R10—(X)n-(ALK)m—的基团，其中R10代表氢，或者是一个可选择地取代的C1-C6烷基、C2-C6烯基、C2-C6炔基、环烷基、芳基或杂环烷基，ALK代表直链或支链的二价C1-C6烷基、C2-C6烯基或C2-C6炔基基团，并且可能被一个或多个非相邻的NH—、—O—或S—连接所中断，X代表NH—、—O—或S—，m和n独立地为0或1；R3代表氢、C1-C6烷基或苄基；而R4如规范中所定义。
• ANTIMICROBIAL AGENTS
  申请人：De Novo Pharmaceuticals Ltd.

  公开号：EP1343753A2

  公开（公告）日：2003-09-17
• US7323596B2
  申请人：——

  公开号：US7323596B2

  公开（公告）日：2008-01-29
• [EN] ANTIMICROBIAL AGENTS<br/>[FR] AGENTS ANTIMICROBIENS
  申请人：NOVO PHARMACEUTICALS LTD DE

  公开号：WO2002050081A2

  公开（公告）日：2002-06-27

  Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(=O) or of formula C(=O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(=O), a hydroxy or amino group; R2 represents a radical of formula R10-(X)n-(ALK)m- wherein R10 represents hydrogen, or an optionally substituted c1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent NH-, -O- or S- linkages, X represents NH-, -O- or S-, and m and n are independently 0 or 1; R3 represents hydrogen, C1-C6alkyl, or benzyl; and R4 is as defined in the specification.