(alphaR)-N-[3-[3-(二氟甲基)苯基]丙基]-alpha-甲基-1-萘甲胺 | 1025064-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: (alphaR)-N-[3-[3-(二氟甲基)苯基]丙基]-alpha-甲基-1-萘甲胺
• 中文别名: (ALPHAR)-N-[3-[3-(二氟甲基)苯基]丙基]-ALPHA-甲基-1-萘甲胺
• 英文名称: [3-(3-difluoromethyl-phenyl)-propyl]-((R)-1-naphthalen-1-yl-ethyl)-amine
• 英文别名: (R)-3-(3-(Difluoromethyl)phenyl)-N-(1-(naphthalen-1-yl)ethyl)propan-1-amine；3-[3-(difluoromethyl)phenyl]-N-[(1R)-1-naphthalen-1-ylethyl]propan-1-amine
• CAS: 1025064-41-8
• 化学式: C₂₂H₂₃F₂N
• 分子量: 339.428
• InChiKey: SVXVVNVAXVGJCF-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (R)-N-(1-(萘-1-基)乙基)-3-(3-(三氟甲基)苯基)丙酰胺 在 lithium aluminium tetrahydride 、 乙酸乙酯 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 51.0h， 生成 (alphaR)-N-[3-[3-(二氟甲基)苯基]丙基]-alpha-甲基-1-萘甲胺
  参考文献：
  名称：

  WO2008/58235

  摘要：

  公开号：

文献信息

• [EN] FLUORINATION PROCESS<br/>[FR] PROCÉDÉ DE FLUORATION
  申请人：UNIV OXFORD INNOVATION LTD

  公开号：WO2016151295A1

  公开（公告）日：2016-09-29

  The present invention relates to a process for producing an organic compound comprising an 18F atom, which process comprises treating a precursor organic compound comprising a –CY2X group with: (i) [18F] fluoride; and (ii) an activator which comprises a compound comprising silver, gold, copper or platinum, or which comprises elemental silver, gold, copper or platinum wherein: X is a leaving group; and each Y is independently selected from F, Cl, Br and H. Also described is the use of an activator which comprises a compound comprising silver, gold, copper or platinum, or which comprises elemental silver, gold, copper or platinum, in a process for producing an organic compound comprising an F atom according to the invention. A kit, composition and compound are also described.

  本发明涉及一种制备含有18F原子的有机化合物的方法，该方法包括用以下物质处理含有–CY2X基团的前体有机化合物：(i) [18F]氟化物；和(ii) 包括银、金、铜或铂化合物的活化剂，或包括元素银、金、铜或铂的活化剂，其中：X是一个离去基团；每个Y独立地选择自F、Cl、Br和H。还描述了使用包括银、金、铜或铂化合物的活化剂，或包括元素银、金、铜或铂的活化剂，按照本发明制备含有F原子的有机化合物的方法。同时还描述了一种试剂盒、组合物和化合物。
• Process for the Preparation of Cinacalcet and Salts Thereof, and Intermediates for Use in the Process
  申请人：Kankan Rajendra Narayanrao

  公开号：US20120053362A1

  公开（公告）日：2012-03-01

  There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-1-naphthylethylamine or a salt of (R)-1-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.

  提供一种制备曼德酸或其衍生物的(R)-或(S)-异构体的1-萘乙胺盐的方法，该方法包括将外消旋的1-萘乙胺与曼德酸或其衍生物反应，以获得(R)-或(S)-异构体的1-萘乙胺盐(III)。这些盐也是本发明的一个方面。还提供了(R)-或(S)-异构体的1-萘乙胺与曼德酸或其衍生物的盐。还提供了一种制备西那卡塞特(I)或其盐的方法，该方法包括将酯(II)与(R)-1-萘乙胺或(R)-1-萘乙胺和曼德酸或其衍生物的盐反应，以获得西那卡塞特，并可选择将西那卡塞特转化为其盐。
• PROCESS FOR THE PREPARATION OF CINACALCET AND SALTS THEREOF, AND INTERMEDIATES FOR USE IN THE PROCESS
  申请人：Cipla Limited

  公开号：EP2403823B1

  公开（公告）日：2015-10-21
• US8575393B2
  申请人：——

  公开号：US8575393B2

  公开（公告）日：2013-11-05
• [EN] METHODS FOR PREPARING CINACALCET HYDROCHLORIDE<br/>[FR] PROCÉDÉS DE PRÉPARATION D'HYDROCHLORURE DE CINACALCET
  申请人：REDDY S LABORTORIES LTD DR

  公开号：WO2008058236A2

  公开（公告）日：2008-05-15

  [EN] There is provided a process for making cinacalcet hydrochloride, said process including a) providing a solution of free base of cinacalcet in a solvent that is an alcohol or alkyl acetate; b) treating said solution with an amount of hydrochloric acid sufficient to convert said free base to said hydrochloride salt; c) adding an anti-solvent to said treated solution in the amount sufficient to precipitate said hydrochloride salt in the form of a solid; and d) isolating said precipitated solid thereby obtaining said cinacalcet hydrochloride. Other aspects, embodiments and variant related to cinacalcet are also provided.
  [FR] L'invention concerne un procédé de préparation d'hydrochlorure de cinacalcet, ledit procédé consistant (a) à utiliser une solution de base libre de cinacalcet dans un solvant qui est un alcool ou un acétate d'alkyle; (b) à traiter ladite solution avec une dose d'acide de chlorhydrate suffisante pour transformer ladite base libre en sel d'hydrochlorure; (c) à ajouter un anti-solvant à ladite solution traitée en quantité suffisante pour précipiter ledit sel d'hydrochlorure sous la forme d'un solide; et (d) à isoler ledit solide précipité de manière à obtenir ledit hydrochlorure de cinacalcet. L'invention concerne également d'autres aspects, modes de réalisation et variantes concernant le cinacalcet.