CJ-12,373

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: CJ-12,373
• 英文别名: (1S,3S)-3-heptyl-1,6,8-trihydroxy-3,4-dihydro-1H-isochromene-7-carboxylic acid
• 化学式: C₁₇H₂₄O₆
• 分子量: 324.374
• InChiKey: PTQJWIMJHPBXTF-GTNSWQLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 CJ-12,373 以 甲醇 为溶剂， 以2.4 mg的产率得到CJ-12,373
  参考文献：
  名称：

  CJ-12,373, a Novel Topoisomerase II Inhibitor: Fermentation, Isolation, Structure Elucidation and Biological Activities.

  摘要：

  A novel isochroman carboxylic acid CJ-12, 373 was isolated from Penicillium sp. CL22557. CJ-12, 373 inhibits both DNA gyrase-mediated supercoiling and relaxation without the formation of a cleavage intermediate, suggesting that CJ-12, 373 inhibits DNA gyrase at a stage distinct from the religation step. CJ-12, 373 is not selective for procaryotic DNA gyrase as it also inhibits relaxation mediated by eukaryotic topoisomerase II. The antimicrobial potency of CJ-12, 373, however, is largely attributed to its inhibition of DNA gyrase.

  DOI：

  10.7164/antibiotics.51.112

文献信息

• CJ-12,373, a Novel Topoisomerase II Inhibitor: Fermentation, Isolation, Structure Elucidation and Biological Activities.
  作者：TAISUKE INAGAKI、KEIJI KANEDA、YUMIKO SUZUKI、HIDEO HIRAI、ETSUKO NOMURA、TATSUO SAKAKIBARA、YUJI YAMAUCHI、LIANG H. HUANG、MICHAEL NORCIA、LILLY M. WONDRACK、JOYCE A. SUTCLIFFE、NAKAO KOJIMA

  DOI：10.7164/antibiotics.51.112

  日期：——

  A novel isochroman carboxylic acid CJ-12, 373 was isolated from Penicillium sp. CL22557. CJ-12, 373 inhibits both DNA gyrase-mediated supercoiling and relaxation without the formation of a cleavage intermediate, suggesting that CJ-12, 373 inhibits DNA gyrase at a stage distinct from the religation step. CJ-12, 373 is not selective for procaryotic DNA gyrase as it also inhibits relaxation mediated by eukaryotic topoisomerase II. The antimicrobial potency of CJ-12, 373, however, is largely attributed to its inhibition of DNA gyrase.