2-(2,3-dimethylphenoxy)-N-methyl-N-[1-(1-propylbenzimidazol-2-yl)ethyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(2,3-dimethylphenoxy)-N-methyl-N-[1-(1-propylbenzimidazol-2-yl)ethyl]acetamide
• 化学式: C₂₃H₂₉N₃O₂
• 分子量: 379.5
• InChiKey: GWECBZNKLJHJLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Aryl and heteroaryl fused aminoalkyl-imidazole derivatives
  申请人：Neurogen Corporation

  公开号：US20020082425A1

  公开（公告）日：2002-06-27

  Disclosed are compounds of the formula: 1 or the pharmaceutically acceptable non-toxic salts thereof wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , A, B, C, and D are variables defined herein. Such compounds useful in treatment of obesity and diabetes. The invention also provides labeled probes for the localization of cellular receptors that are involved in the modulation of blood glucose levels.

  本发明揭示了以下公式的化合物：1或其药学上可接受的非毒性盐，其中X，R1，R2，R3，R4，R5，R6，R7，A，B，C和D是在此定义的变量。这些化合物在肥胖和糖尿病的治疗中有用。本发明还提供了用于定位参与调节血糖水平的细胞受体的标记探针。
• ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIDIABETICS
  申请人：NEUROGEN CORPORATION

  公开号：EP1165519A1

  公开（公告）日：2002-01-02
• US6271241B1
  申请人：——

  公开号：US6271241B1

  公开（公告）日：2001-08-07
• [EN] ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIDIABETICS<br/>[FR] DERIVES D'AMINOALKYLE-IMIDAZOLE CONDENSES ARYLES ET HETEROARYLES ET LEUR UTILISATION COMME ANTIDIABETIQUES
  申请人：NEUROGEN CORP

  公开号：WO2000059887A1

  公开（公告）日：2000-10-12

  Disclosed are compounds of formula (I) or the pharmaceutically acceptable non-toxic salts thereof wherein X, R1, R2, R3, R4, R5, R6, R7, A, B, C, and D are variables defined herein. Such compounds useful in treatment of obesity and diabetes. The invention also provides labeled probes for the localization of cellular receptors that are involved in the modulation of blood glucose levels.