(±)-N-乙基-alpha-甲基苯乙胺盐酸盐 | 16105-78-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (±)-N-乙基-alpha-甲基苯乙胺盐酸盐
• 中文别名: DL-N-乙基苯异丙胺盐酸盐
• 英文名称: N-ethylamphetamine hydrochloride
• 英文别名: dl-N-ethylamphetamine hydrochloride；ethyl-(1-methyl-2-phenyl-ethyl)-amine; hydrochloride；Aethyl-(1-methyl-2-phenyl-aethyl)-amin; Hydrochlorid；(+/-)-N-ethyl-α-methylphenethylamine hydrochloride；N-ethyl-1-phenylpropan-2-amine;hydron;chloride
• CAS: 16105-78-5
• 化学式: C₁₁H₁₇N*ClH
• 分子量: 199.724
• InChiKey: HFBTZBOJTFIRAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 储存条件：
  | 2-8°C |

反应信息

• 作为产物：
  描述：

  乙胺 、 苯基丙酮 在 platinum(IV) oxide 盐酸 、 氢气 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以88%的产率得到(±)-N-乙基-alpha-甲基苯乙胺盐酸盐
  参考文献：
  名称：

  Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives

  摘要：

  1. Amphetamine (AM) and five amphetamine derivatives, N-ethylamphetamine (NEA), N-butylamphetamine (NBA), 4-methoxyamphetamine (RI-AM), 4-methoxy-N-ethylamphetamine (M-NEA) and 4-methoxy-N-butylamphetamine (M-NBA) were incubated with microsomal preparations from cells expressing human CYP2D6 to determine whether the enzyme was capable of catalyzing the direct ring oxidation of all substrates; the N-dealkylation of NEA, NEA, M-NEA and M-NBA; and the O-demethylation of M-AM, M-NEA and M-NBA.2. None of the six compounds examined was N-dealkylated to any extent.3. The only metabolites produced from,AM, NEA and NEA were the corresponding ring 4-hydroxylated compounds, and the rates of formation were low.4. All ring l-methoxylated substrates were efficiently O-demethylated by CYP2D6 to their corresponding phenols. The size of the N-alkyl group influenced the rates of formation of these phenolamines. In contrast to reported findings with 2- and 3-methoxyamphetamines, none of the 4-methoxyamphetamines was ring-oxidized in the CYP2D6 enzyme system to 2- or 3-hydroxy-4-methoxyamphetamines or to dihydroxy-amphetamines.

  DOI：

  10.1080/004982599238344

文献信息

• Treatment of ADHD
  申请人：Gosforth Centre (Holdings) Pty Ltd

  公开号：EP2505197A1

  公开（公告）日：2012-10-03

  A method is described for treating attention deficit hyperactivity disorder (ADHD), by administering to the individual an anti-epileptic mood stabiliser at a dose which is sub-therapeutic for mood stabilisation, optionally in combination with a psychostimulant. Also described is a method of improving reading comprehension and/or fluency in an individual suffering from learning difficulties which method comprises administering to the individual an anti-epileptic mood stabiliser.

  本文描述了一种治疗注意力缺陷多动障碍（ADHD）的方法，即给患者服用抗癫痫情绪稳定剂，剂量为稳定情绪的次治疗剂量，可选择与精神兴奋剂联合使用。还描述了一种改善学习困难患者阅读理解和/或流畅性的方法，该方法包括给患者服用抗癫痫情绪稳定剂。
• Compositions and methods for treating psychiatric disorders
  申请人：GOSFORTH CENTRE (HOLDINGS) PTY LTD.

  公开号：US10028971B2

  公开（公告）日：2018-07-24

  Methods of treating psychiatric disorders are provided which include administration of one or more anti-epileptic agents and, optionally, one or more a psychostimulants. Also provided are pharmaceutical compositions comprising, in combination, one or more anti-epileptic agents and one or more psychostimulants. Psychiatric disorders include those associated with impaired cognitive processing, degenerative disorders such as Mild Cognitive Impairment, Parkinson's disease, dementia, non-compliance with therapeutic regimes and eating disorders, although without limitation thereto.

  提供了治疗精神障碍的方法，其中包括服用一种或多种抗癫痫剂，以及可选的一种或多种精神兴奋剂。此外，还提供了由一种或多种抗癫痫剂和一种或多种精神兴奋剂组合而成的药物组合物。精神障碍包括与认知处理受损、退化性障碍（如轻度认知障碍）、帕金森病、痴呆症、不遵从治疗方案和饮食失调有关的疾病，但并不限于此。
• SU, JINGYU;ZHENG, YISHEN;WU, JIANQUING;TANG, GANMING;ZENG, LONGMEI, CHEM. J. CHIN. UNIV., 9,(1988) N 2, 134-139
  作者：SU, JINGYU、ZHENG, YISHEN、WU, JIANQUING、TANG, GANMING、ZENG, LONGMEI

  DOI：——

  日期：——
• NEW PSYCHOSTIMULANT AGENT
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0284621B1

  公开（公告）日：1995-01-18
• TREATMENT OF ADHD
  申请人：Gosforth Centre (Holdings) Pty Ltd

  公开号：EP2129369A1

  公开（公告）日：2009-12-09