(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;2-hydroxypropane-1,2,3-tricarboxylic acid

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;2-hydroxypropane-1,2,3-tricarboxylic acid
• 化学式: C23H27NO10
• 分子量: 477.5
• InChiKey: MBGMONKTIXKSDS-VYKNHSEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.05
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  185
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• [EN] SYNTHESIS OF MORPHINE AND RELATED DERIVATIVES<br/>[FR] SYNTHÈSE DE LA MORPHINE ET DE DÉRIVÉS ASSOCIÉS
  申请人：UNIV TEXAS

  公开号：WO2010132570A1

  公开（公告）日：2010-11-18

  The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof, wherein the starting compound is biphenyl.

  本发明涉及一种合成迷迭香碱、吗啡、中间体、盐和衍生物的方法，其中起始化合物为联苯。
• [EN] CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF<br/>[FR] TRANSFORMATIONS CHIMIQUES DE (-)-CODÉINE POUR FOURNIR DES DÉRIVÉS DE CODÉINE ET DE MORPHINE CORRESPONDANTS
  申请人：UNIV TEXAS

  公开号：WO2013184902A1

  公开（公告）日：2013-12-12

  The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions.

  本发明涉及吗啡、可待因、中间体、盐及其衍生物的合成方法。在优选实施方式中，本发明涉及改善所述可待因和吗啡相关衍生物及其中间体的效率、立体选择性和总产率的方法。本发明涉及新的可待因和吗啡相关衍生物组合物。
• Efficient Synthesis Of Morphine And Codeine
  申请人：Magnus Philip D.

  公开号：US20100292475A1

  公开（公告）日：2010-11-18

  The present invention relates to methods for the synthesis of morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

  本发明涉及吗啡、中间体、盐和衍生物的合成方法。在优选实施例中，本发明涉及改善吗啡、吗啡相关衍生物和中间体的效率和总产量的方法。在进一步实施例中，本发明涉及改善迷迭香碱及其中间体的效率和总产量的方法。
• Efficient Synthesis Of Galanthamine
  申请人：Magnus Philip D.

  公开号：US20100292466A1

  公开（公告）日：2010-11-18

  The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

  本发明涉及合成迷达唑啉、吗啡、中间体、盐和衍生物的方法。在优选实施例中，本发明涉及提高吗啡、吗啡相关衍生物和中间体的效率和总产率的方法。在进一步的实施例中，本发明涉及提高迷达唑啉及其中间体的效率和总产率的方法。
• Controlled release formulations
  申请人：Moshman Michael

  公开号：US20050175679A1

  公开（公告）日：2005-08-11

  The present invention relates to controlled release transmucosal formulations which mediate absorption and methods of use comprising a pharmaceutically active agent, preferably morphine, and a water soluble polymer, chitosan, and preferably one more antioxidants, one or more antimicrobial agents, and water.

  本发明涉及控制释放的粘膜给药配方，用于介导吸收的方法，包括一种药物活性剂，优选为吗啡，以及一种水溶性聚合物，壳聚糖，以及优选的一种或多种抗氧化剂，一种或多种抗微生物剂和水。