[hydroxy-[[(2R,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: [hydroxy-[[(2R,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₀H₁₇N₂O₁₄P₃
• 分子量: 482.17
• InChiKey: NHVNXKFIZYSCEB-BWZBUEFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  239
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• VERFAHREN ZUR FESTPHASENGESTÜTZTEN HERSTELLUNG PHOSPHATVERBRÜCKTER NUCLEOSID-KONJUGATE
  申请人：Universität Hamburg

  公开号：EP2427470B1

  公开（公告）日：2014-08-20
• LIQUID PROTEIN FORMULATIONS CONTAINING ORGANOPHOSPHATES
  申请人：Arsia Therapeutics, Inc.

  公开号：US20150071921A1

  公开（公告）日：2015-03-12

  Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous (SC) or intramuscular (IM) injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and organophosphates. The viscosity of the formulation is significantly reduced by the addition of one or more organophosphates.
• METHOD FOR THE SOLID-PHASE BASED SYNTHESIS OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES
  申请人：UNIVERSITÄT HAMBURG

  公开号：US20150361124A1

  公开（公告）日：2015-12-17

  A method for producing phosphate-bridged nucleoside conjugates, in particular poly- or oligonucleosides. In the method, an immobilized cyclosaligenyl derivative of a nucleoside, nucleotide, poly- or oligonucleotide, poly- or oligonucleoside, or an analog thereof, is synthesized, and the subsequent reaction with a nucleophile yields the desired phosphate-bridged nucleoside conjugate, which may subsequently be released from the solid phase.
• Inorganic-organic hybrid compound
  申请人：Karlsruher Institut für Technologie

  公开号：US20170112948A1

  公开（公告）日：2017-04-27

  The present invention relates to an inorganic-organic hybrid compound as ionic compound, composed of an inorganic cation and of an organic active ingredient anion and also, optionally, of an organic fluorescent dye anion.
• US7314928B2
  申请人：——

  公开号：US7314928B2

  公开（公告）日：2008-01-01