2-(3-imidazol-1-ylpropylamino)-4-pyridin-4-yl-1H-pyrimidin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(3-imidazol-1-ylpropylamino)-4-pyridin-4-yl-1H-pyrimidin-6-one
• 化学式: C₁₅H₁₆N₆O
• 分子量: 296.33
• InChiKey: QVLZGJBBHAOYEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] 2-(ARYLALKYLAMINO)PYRIMIDONE DERIVATIVES AND 2-(HETEROARYLALKYLAMINO)PYRIMIDONE DERIVATIVES<br/>[FR] DERIVES DE 2-(ARYLALKYLAMINO)PYRIMIDONE ET DERIVES DE 2-(HETEROARYLALKYLAMINO)PYRIMIDONE
  申请人：SANOFI SYNTHELABO

  公开号：WO2001070727A1

  公开（公告）日：2001-09-27

  A pyrimidone derivative represented by formula (I) or a salt thereof, wherein R2 represents a hydrogen atom, a C1-2 perhalogenated alkyl group or a C1-6 alkyl group which may be substituted by 1 to 3 groups selected from a halogen atom, an amino, a (C1-6-alkyl)carbonylamino group, a (C1-6-alkoxy)carbonylamino group, a C1-6 alkylsulfonylamino group or a phenyl group; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or a halogen atom; and when n represents 1 to 10, the R1 represents an unsubstituted naphth-1-yl group; an unsubstituted naphth-2-yl group; a C6,10 aryl group substituted by 1 to 3 substituents (A); a furan ring, thiophene ring, pyrrole ring or imidazole ring, the rings being optionally substituted by 1 to 3 substituents (A); an indole ring, attached by a carbon atom, optionally substituted by 1 to 3 substituents (A), the nitrogen of the indole ring being optionally substituted by a C1-6 alkyl group; a pyridine ring optionally substituted by 1 to 3 substituents (B); when n represents 4 to 10 then R1 can represent in addition an unsubstituted phenyl group; and when n represents 1 to 3 and R1 represents an unsubstituted phenyl group then R2 represents a C1-2 perhalogenated alkyl group or a C1-6 alkyl substituted by 1 to 3 groups selected from a halogen atom, an amino, a (C1-6-alkyl)carbonylamino group, a (C1-6-alkoxy)carbonylamino group and a C1-6 alkylsulfonylamino group. And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β.