1(2H)-吡啶羧酸,5-氰基-,乙基酯 | 52659-57-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 中文名称: 1(2H)-吡啶羧酸,5-氰基-,乙基酯
• 中文别名: 海兔毒素
• 英文名称: aplysiatoxin
• 英文别名: (1S,3R,4S,5S,9R,13S,14R)-3-[(2S,5S)-5-(2-bromo-5-hydroxyphenyl)-5-methoxypentan-2-yl]-13-hydroxy-9-[(1R)-1-hydroxyethyl]-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione
• CAS: 52659-57-1
• 化学式: C₃₂H₄₇BrO₁₀
• 分子量: 671.623
• InChiKey: RHJPBGWFGOAEID-BEDNPZBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  141
• 氢给体数：
  3
• 氢受体数：
  10

制备方法与用途

类别：有毒物质

毒性分级：剧毒

急性毒性：腹腔-小鼠 LD50: 0.118 毫克/公斤

可燃性危险特性：可燃，火场排出辛辣刺激烟雾

储运特性：库房低温、通风、干燥；与食品原料分开存放

灭火剂：水、二氧化碳、干粉、砂土

反应信息

• 作为产物：
  描述：

  debromo aplysiatoxin 在 溴 、 sodium phosphate 、 sodium bromide 作用下， 以 甲醇 为溶剂， 以16 mg的产率得到1(2H)-吡啶羧酸,5-氰基-,乙基酯
  参考文献：
  名称：

  Absolute stereochemistries of the aplysiatoxins and oscillatoxin A

  摘要：

  DOI：

  10.1021/jo00187a035

文献信息

• [EN] PKC ACTIVATORS AND COMBINATIONS THEREOF<br/>[FR] ACTIVATEURS DE PKC ET DES COMBINAISONS DE CEUX-CI
  申请人：BRNI NEUROSCIENCES INST

  公开号：WO2013071282A1

  公开（公告）日：2013-05-16

  The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

  本公开涉及PKC激活剂及其组合物。本公开进一步涉及其组成物、试剂盒、用途和方法。
• PKC activators and combinations thereof
  申请人：Cognitive Research Enterprises, Inc.

  公开号：US10821079B2

  公开（公告）日：2020-11-03

  The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

  本公开涉及PKC激活剂及其组合物。该公开进一步涉及这些组合物的组成、试剂盒、用途和方法。
• [EN] HALOGENATED ESTERS OF CYCLOPROPANATED UNSATURATED FATTY ACIDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] ESTERS HALOGÉNÉS D'ACIDES GRAS INSATURÉS CYCLOPROPANÉS POUR UTILISATION DANS LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：BRNI NEUROSCIENCES INST

  公开号：WO2015058191A1

  公开（公告）日：2015-04-23

  The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monunsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

  本公开描述了从卤代酯类不饱和脂肪酸及其衍生物中选择的新型PKC-ε激活剂，包括多不饱和脂肪酸和单不饱和脂肪酸的卤代酯及其衍生物。该公开还涉及使用这些卤代酯的组合物、试剂盒和治疗方法。
• Rigid pyrrolidone modulators of pkc
  申请人：——

  公开号：US20040019018A1

  公开（公告）日：2004-01-29

  Compounds of the general formula (I): wherein substituents at R 1 , R 2 , R 3 and R 4 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC modulators and are useful for treating diseases, such as, for example, cancers including prostate cancer, inflammatory, autoimmune and neurological disorders including Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), processes for preparing compounds of formula (I), and intermediates useful for preparing compounds of formula (I).

  通式（I）的化合物：其中R1、R2、R3和R4的取代基具有规范中定义的任何值，以及它们的药学上可接受的盐，是PKC调节剂，可用于治疗疾病，例如癌症（包括前列腺癌）、炎症、自身免疫和神经系统疾病（包括阿尔茨海默病）。还公开了包括通式（I）化合物的制药组合物、制备通式（I）化合物的方法，以及制备通式（I）化合物有用的中间体。
• METHODS AND COMPOSITIONS FOR IDENTIFYING, PRODUCING AND USING PLANT-DERIVED PRODUCTS FOR MODULATING CELL FUNCTION AND AGING
  申请人：McDaniel David H.

  公开号：US20110159121A1

  公开（公告）日：2011-06-30

  Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.

  本文提供了在体外培养细胞的方法，以利用细胞的生化生产能力来制造代谢产物，这些代谢产物被评估和收获其生物效应。还提供了用于评估这些培养细胞提取物的系统，以表征其生物活性，特别是对健康、幸福、长寿、DNA维护、线粒体健康和/或生成等方面的影响。还提供了具有生物活性的提取物、其组分以及制成的组合物（如化妆品或制药制剂）。