7-(1H-indol-3-ylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7-(1H-indol-3-ylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
• 化学式: C₁₈H₁₈N₂O₂S
• 分子量: 326.4
• InChiKey: ZZKOQSIQUZLCDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  70.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment cns disorders
  申请人：Ahmed Mahmood

  公开号：US20050176759A1

  公开（公告）日：2005-08-11

  Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

  发明了非肽类TPO模拟剂。还发明了一种治疗血小板减少症的方法，包括在需要的哺乳动物，包括人类中，向这种哺乳动物施用所选羟基-1-偶氮苯衍生物的有效量。
• 7-SULFONYL-3-BENZAZEPINE DERIVATIVES AS MODULATORS OF THE DOPAMINE RECEPTOR AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1456178A1

  公开（公告）日：2004-09-15
• [EN] 7-SULFONYL-3-BENZAZEPINE DERIVATIVES AS MODULATORS OF THE DOPAMINE RECEPTOR AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS<br/>[FR] DERIVES DE 7-SULFONYL-3-BENZAZEPINE UTILISES COMME MODULATEURS DU RECEPTEUR A LA DOPAMINE ET UTILISATION DE CES DERNIERS DANS LE TRAITEMENT DES TROUBLES DU SYSTEME NERVEUX CENTRAL
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003062205A1

  公开（公告）日：2003-07-31

  The present invention relates to novel sulfone compounds of formula (I) or a pharmaceutically acceptable salt thereof: having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders such as psychotic disorders.