N-(2,6-diisopropylphenyl)-N'-[4-(2-methylphenyl)-2-phenylpyrimidin-5-yl]urea | 162508-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(2,6-diisopropylphenyl)-N'-[4-(2-methylphenyl)-2-phenylpyrimidin-5-yl]urea
• 英文别名: 1-[2,6-Di(propan-2-yl)phenyl]-3-[4-(2-methylphenyl)-2-phenylpyrimidin-5-yl]urea
• CAS: 162508-79-4
• 化学式: C₃₀H₃₂N₄O
• 分子量: 464.61
• InChiKey: PBVGJQJMUWOARG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP0638557A1

  公开（公告）日：1995-02-15

  The present invention relates to a compound represented by the general formula (I): [wherein R¹ is a lower alkyl group, a lower cycloalkyl group, a lower alkoxy group, an aliphatic cyclic amino group which may be substituted by one or more lower alkyl groups, or a phenyl group which may be substituted by one or more halogen atoms, R² is a hydrogen atom or a lower alkyl group, R³ and R⁴, which may be the same or different, are hydrogen atoms, halogen atoms, lower alkyl groups, lower haloalkyl groups, lower alkoxy groups or lower alkylthio groups, R⁵, R⁶ and R⁷, which may be the same or different, are hydrogen atoms, halogen atoms, lower alkyl groups, lower haloalkyl groups, lower alkoxy groups, lower alkylthio groups or lower dialkylamino groups, and X is =N- or =CH-] or a pharmacologically acceptable salt thereof, which has inhibitory effect on acyl-CoA:cholesterol O-acyltransferase (ACAT), a process for producing said compound, and uses of said compound.

  本发明涉及通式 (I) 所代表的化合物： [其中 R¹ 是低级烷基、低级环烷基、低级烷氧基、可被一个或多个低级烷基取代的脂族环状氨基或可被一个或多个卤素原子取代的苯基，R² 是氢原子或低级烷基，R³ 和 R⁴ 可以相同或不同，是氢原子、卤素原子、低级烷基、低级卤代烷基、低级烷氧基或低级烷硫基、R⁵、R⁶和 R⁷可以相同或不同，它们是氢原子、卤素原子、低级烷基、低级卤代烷基、低级烷氧基、低级烷硫基或低级二烷基氨基，X 是 =N- 或 =CH-]或其药理学上可接受的盐，对酰基-CoA 具有抑制作用：胆固醇 O-酰基转移酶 (ACAT)具有抑制作用的化合物或其药理学可接受盐、生产所述化合物的工艺以及所述化合物的用途。
• US5500424A
  申请人：——

  公开号：US5500424A

  公开（公告）日：1996-03-19