3,5-Di-tert-butyl-4-hydroxy-N-isobutylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Di-tert-butyl-4-hydroxy-N-isobutylbenzamide
• 英文别名: 3,5-ditert-butyl-4-hydroxy-N-(2-methylpropyl)benzamide
• 化学式: C₁₉H₃₁NO₂
• 分子量: 305.5
• InChiKey: ZRUCYBDNMKWMBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Caged ligands and uses thereof
  申请人：Lawrence S. David

  公开号：US20060240088A1

  公开（公告）日：2006-10-26

  Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound with light. Also provided are cells transfected with a gene of interest and a gene encoding a receptor, the gene of interest operably linked to a genetic element capable of being induced by the receptor when bound to a ligand, and the receptor not naturally present in the species of the cell. The cells also comprise a caged ligand of the receptor. Additionally provided are methods of inducing a gene of interest in the above cells. Also provided are methods of repressing a gene of interest in a cell using caged ligands of receptors. Methods are additionally provided for inducing elimination of a target sequence in a cell of a species, using a caged ligand and a recombinase.

  提供了包含与哺乳动物中自然不存在的受体特异反应的配体的笼式化合物。当用光照射化合物时，笼子会从配体中释放出来。还提供了转染了感兴趣基因和编码受体的基因的细胞，感兴趣基因与能够被受体诱导的基因元件可操作地连接在一起，当受体与配体结合时，受体在该细胞物种中自然不存在。细胞还包括受体的笼式配体。此外，提供了在上述细胞中诱导感兴趣基因的方法。还提供了使用受体的笼式配体在细胞中抑制感兴趣基因的方法。此外，还提供了使用笼式配体和重组酶在物种的细胞中诱导靶序列的消除的方法。
• Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
  申请人：Palli Reddy Subba

  公开号：US20050266457A1

  公开（公告）日：2005-12-01

  This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

  本发明涉及生物技术或遗传工程领域。具体而言，本发明涉及基因表达领域。更具体地说，本发明涉及新颖的替代突变受体及其在核受体为基础的诱导基因表达系统中的应用，以及在宿主细胞中调节基因表达的方法，用于基因治疗、大规模蛋白质和抗体生产、基于细胞的高通量筛选分析、功能基因组学和调节转基因生物的性状等应用。
• Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression
  申请人：PALLI Subba Reddy

  公开号：US20120185954A1

  公开（公告）日：2012-07-19

  This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

  本发明涉及生物技术或遗传工程领域。具体而言，本发明涉及基因表达领域。更具体而言，本发明涉及新型替代突变受体及其在核受体为基础的诱导基因表达系统中的应用，以及调节宿主细胞基因表达的方法，用于基因治疗、大规模蛋白质和抗体生产、细胞基础高通量筛选分析、功能基因组学和转基因生物特征的调节等应用。
• Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System
  申请人：Intrexon Corporation

  公开号：US20140322812A1

  公开（公告）日：2014-10-30

  This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

  本发明涉及生物技术或遗传工程领域。具体而言，本发明涉及基因表达领域。更具体地说，本发明涉及新颖的替换突变受体及其在核受体为基础的可诱导基因表达系统中的应用，以及调节宿主细胞中基因表达的方法，用于基因治疗、大规模蛋白质和抗体生产、基于细胞的高通量筛选分析、功能基因组学和调控转基因生物特征等应用。
• Multiple inducible gene regulation system
  申请人：Intrexon Corporation

  公开号：EP2305824A1

  公开（公告）日：2011-04-06

  The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.

  本发明涉及生物技术或基因工程领域。更具体地说，本发明涉及一种多重可诱导基因调控系统，该系统在细胞内发挥作用，可同时控制多个基因的定量表达。