1,1,3,3,5,5,7,7-八甲基四硅氧烷 | 1000-05-1

• 物质功能分类: 化学试剂 - 硅烷试剂
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 1,1,3,3,5,5,7,7-八甲基四硅氧烷
• 中文别名: 1,1,3,3,5,5,7,7-八甲基四硅烷；八甲基四硅氧烷
• 英文名称: 1,1,3,3,5,5,7,7-octamethyltetrasiloxane
• 英文别名: Dimethylsilyloxy-[dimethylsilyloxy(dimethyl)silyl]oxy-dimethylsilane
• CAS: 1000-05-1
• 化学式: C₈H₂₆O₃Si₄
• mdl: MFCD00039789
• 分子量: 282.635
• InChiKey: MMAKNNYIZYDWTD-UHFFFAOYSA-N

物化性质

• 熔点：
  <0°C
• 沸点：
  169 °C
• 密度：
  0.863
• 闪点：
  78°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2934999090
• 包装等级：
  III
• 危险类别：
  3
• 危险性防范说明：
  P501,P240,P210,P233,P243,P241,P242,P264,P280,P370+P378,P337+P313,P305+P351+P338,P303+P361+P353,P403+P235
• 危险品运输编号：
  1993
• 危险性描述：
  H319,H225
• 储存条件：
  2~8℃

制备方法与用途

有机硅中间体

反应信息

• 作为反应物：
  描述：

  1,1,3,3,5,5,7,7-八甲基四硅氧烷 在 三氯异氰尿酸 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以83%的产率得到1,7-二氯八甲基四硅氧烷
  参考文献：
  名称：

  Building blocks for oligomeric siloxanes –selective chlorination of hydrido-siloxanes

  摘要：

  A new method was developed to achieve highly selective monochlorination of alpha,omega-dihydridosiloxanes, ((H)Me2SiO-(SiMe2O)(n)-SiMe2(H), n = 0-2; (H)R2Si-O-SiR2(H); R= Me, 'Pr, Ph; 3,5-dihydridooctamethyl tetrasiloxane, Me3SiO-(Si(H)MeO)(2) -SiMe3) with trichloroisocyanuric acid (TCCA). The dependence of the selectivity of the monochlorination on the siloxane chain length is also discussed. (C) 2018 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2018.08.022
• 作为产物：
  描述：

  1,7-二氯八甲基四硅氧烷 在 四氢呋喃 、 ^+- 作用下， 反应 2.0h， 生成 1,1,3,3,5,5,7,7-八甲基四硅氧烷 、 1,7-Dibutyloxy-octamethyl-tetrasiloxan
  参考文献：
  名称：

  Knott, Wilfried, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1997, vol. 52, # 5, p. 629 - 634

  摘要：

  DOI：
• 作为试剂：
  描述：

  环己烯 在 1,1,3,3,5,5,7,7-八甲基四硅氧烷 、 三(五氟苯基)硼烷 作用下， 以 二氯甲烷 为溶剂， 以46 %的产率得到cyclohexyldimethylsilane
  参考文献：
  名称：

  JP2022/67267

  摘要：

  公开号：

文献信息

• Design and phase transition behavior of siloxane-based monomeric and dimeric liquid crystals bearing cholesteryl mesogenic groups
  作者：Kaito Katsuki、Kosuke Kaneko、Kimiyoshi Kaneko、Riki Kato、Nobuyoshi Miyamoto、Tomonori Hanasaki

  DOI：10.1016/j.jorganchem.2019.02.016

  日期：2019.4

  A series of siloxane-based monomeric and dimeric liquid crystals (LCs) bearing cholesteryl mesogenic groups were newly synthesized and their phase transition behavior was investigated by polarized optical microscopy (POM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). All the siloxane-based LCs obtained in this study showed a smectic A phase in a wide temperature range. Among

  新合成了一系列带有胆固醇基介晶基团的硅氧烷基单体和二聚液晶（LC），并通过偏振光学显微镜（POM），差示扫描量热法（DSC）和X射线衍射（XRD）研究了它们的相变行为）。在这项研究中获得的所有基于硅氧烷的LC均在较宽的温度范围内显示出近晶A相。在获得的基于硅氧烷的LC中，仅发现在间隔基的中央部分具有最短硅氧烷单元的二聚LC除了近晶A相之外还显示出手性向列相和蓝相。根据构象研究了基于硅氧烷的二聚LC的热性能差异。此外，
• Composition for separating mixtures
  申请人：Procter Ian

  公开号：US20070249502A1

  公开（公告）日：2007-10-25

  Therefore, there is provided herein in one specific embodiment a composition comprising: a) at least one silicone surfactant, and where silicone of silicone surfactant (a) has the general structure of: M a 1 M b 2 D c 1 D d 2 T e 1 T f 2 Q g ; and, 2≦( a+b+c+d+e+f+g )≦100; and, b) a mixture comprising an aqueous phase, a solid filler phase and optionally an oil phase that is substantially insoluble in said aqueous phase.

  因此，在一个具体实施例中提供了一种组合物，包括：a) 至少一种硅表面活性剂，其中硅表面活性剂(a)的硅具有以下一般结构：Ma1Mb2Dc1Dd2Te1Tf2Qg；以及，2≦(a+b+c+d+e+f+g)≦100；和，b) 一种混合物，包括水相、固体填料相和可选地在所述水相中基本不溶的油相。
• SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS
  申请人：DSM IP ASSETS B.V.

  公开号：US20170088564A1

  公开（公告）日：2017-03-30

  Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R 1 is H or CH 3 , a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R 51 , R 52 , R 53 are independently an alkyl, alkyl ether, urethane, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group Z attached wherein said hydrophilic group Z is selected from the group of poly(ethylene glycol), poly(propylene glycol), poly(ethyl oxazoline), poly(methyl oxazoline), hyaluronic acid, or combinations thereof, preferably to the terminal end of R 51 , R 52 , R 53 , X is O or NR 54 , where R 54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R 2 and R 3 is independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group, preferred R 2 and R 3 include methyl, ethyl, trimethylsiloxy and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, substituted and unsubstituted heterocyclic groups. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-biologic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices.

  公开了一种具有式I的含有反应单体的硅含有亲水端基，用于制造生物相容性医疗器械，其中R1为H或CH3，a为0或1，p为1到6的整数，q为1到3的整数，对于每个q，端基R51、R52、R53独立地为烷基、烷基醚、脲、三甲基硅氧基团或取代或未取代的芳香基，并且其中至少一个具有连接的亲水基团Z，其中所述的亲水基团Z选自聚乙二醇、聚丙烯醇、聚乙基噁唑烷、聚甲基噁唑烷、透明质酸或其组合的群组，优选地连接到R51、R52、R53的末端，X为O或NR54，其中R54为H或具有1到4个碳的一价烷基，n为1到100的整数，R2和R3独立地为烷基、烷基醚、三甲基硅氧基团或取代或未取代的芳香基，优选的R2和R3包括甲基、乙基、三甲基硅氧基和苯基，L为二价连接剂，包括取代和未取代的具有1-14个碳原子的烷基烃基，可能是直链或支链，取代和未取代的具有2-12个碳原子的烷氧基团，聚醚，噁唑烷，取代和未取代的杂环基团。这些反应单体将氧透过性硅组分与具有能够到达器械生物界面的亲水末端基团结合，从而提供有利于制造医疗器械的体积和表面特性，特别是眼科器械。
• [EN] ABSORBENT COMPOSITIONS INCLUDING AMINO-SILOXANES<br/>[FR] COMPOSITIONS D'ABSORBANT COMPRENANT DES AMINOSILOXANES
  申请人：GE OIL & GAS INC

  公开号：WO2018190815A1

  公开（公告）日：2018-10-18

  An absorbent composition including an amino-siloxane is presented. The amino- siloxane includes structure (I): wherein R1 is independently at each occurrence a C1-C6 aliphatic or aromatic radical; R2 is independently at each occurrence a C2-C10 aliphatic or aromatic radical; and R3 is independently at each occurrence a C1-C18 aliphatic or aromatic radical or R4, wherein R4 comprises structure (II): wherein X is independently at each occurrence an electron donating group; and n is at least 1. Methods of reducing an amount of carbon dioxide in a process stream using the absorbent composition are also presented.

  提供了一种包含氨基硅氧烷的吸收剂组合物。氨基硅氧烷包括结构（I）：其中R1在每次出现时独立地为C1-C6脂肪或芳香基团；R2在每次出现时独立地为C2-C10脂肪或芳香基团；R3在每次出现时独立地为C1-C18脂肪或芳香基团或R4，其中R4包括结构（II）：其中X在每次出现时独立地为电子给体基团；n至少为1。还提供了使用该吸收剂组合物减少工艺流中二氧化碳量的方法。
• [EN] SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS<br/>[FR] SILICONE CONTENANT DES MONOMÈRES PORTANT DES GROUPES TERMINAUX HYDROPHILES
  申请人：DSM IP ASSETS BV

  公开号：WO2012104349A1

  公开（公告）日：2012-08-09

  Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R1 is H or CH3, a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R51, R52, R53 are independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group attached, preferably to the terminal end of R51, R52, R53, X is O or NR54, where R54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R2 and R3 are independently an alkyl, alkyl ether, or a substituted or non-substituted aromatic group, preferred R2 and R3 include methyl, ethyl, and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, and substituted and unsubstituted heterocyclic groups. Suitable substituents include aryl, amine, ether, amide, hydroxyl groups, combinations thereof and the like. In another embodiment, L comprises a straight or branched alkylene group having 2 to 12 carbons. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-biologic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices.

  本发明揭示了具有公式I的含有反应单体的硅氧烷，其末端基团具有亲水性，在生物相容性医疗器械的制造中有用。在公式中，R1为H或CH3，a为0或1，p为1到6的整数，q为1到3的整数，对于每个q，末端基团R51、R52、R53独立地是烷基、烷基醚、三甲基硅氧基团或取代或未取代的芳香基，并且它们中至少有一个连接有亲水基，最好连接在R51、R52、R53的末端，X为O或NR54，其中R54为H或具有1到4个碳的一价烷基，n为1到100的整数，R2和R3独立地是烷基、烷基醚或取代或未取代的芳香基，首选的R2和R3包括甲基、乙基和苯基，L为二价连接剂，包括取代和未取代的具有1-14个碳原子的烷基烃基，可能是直链或支链，取代和未取代的具有2-12个碳原子的烷氧基，聚醚，噁唑烯，取代和未取代的杂环基。合适的取代基包括芳基、胺、醚、酰胺、羟基等，另一实施方式中，L包括具有2到12个碳原子的直链或支链烷基。这些含有反应单体的硅氧烷结合了氧渗透性硅氧部分和具有能够到达器械生物界面的亲水末端基团，从而提供了在制造医疗器械中有用的体积和表面特性，特别是眼科器械。