N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N''-[3-(4-hydroxyphenoxy)propyl]-guanidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N''-[3-(4-hydroxyphenoxy)propyl]-guanidine
• 英文别名: 3,5-diamino-6-chloro-N-[N'-[3-(4-hydroxyphenoxy)propyl]carbamimidoyl]pyrazine-2-carboxamide
• 化学式: C₁₅H₁₈ClN₇O₃
• 分子量: 379.8
• InChiKey: FSNVNDOONHTMFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  175
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• SODIUM CHANNEL BLOCKERS
  申请人：Parion Sciences, Inc.

  公开号：EP1485359B1

  公开（公告）日：2007-12-05
• METHODS OF REDUCING RISK OF INFECTION FROM PATHOGENS
  申请人：JOHNSON Michael R.

  公开号：US20110144338A1

  公开（公告）日：2011-06-16

  Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
• Methods of Reducing Risk of Infection from Pathogens
  申请人：JOHNSON Michael R.

  公开号：US20120165342A1

  公开（公告）日：2012-06-28

  Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
• US7192958B2
  申请人：——

  公开号：US7192958B2

  公开（公告）日：2007-03-20
• US7192959B2
  申请人：——

  公开号：US7192959B2

  公开（公告）日：2007-03-20