2-chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid | 639825-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid
• 英文别名: 2-chloro-5-(2, 3, 5, 6-tetrafluoro-4-trifluoromethylbenzylamuno)benzoic acid；2-Chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid；2-chloro-5-[[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]methylamino]benzoic acid
• CAS: 639825-06-2
• 化学式: C₁₅H₇ClF₇NO₂
• 分子量: 401.668
• InChiKey: CHGSKXXFHOAJHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  5-氨基-2-氯苯甲酸 、 2,3,5,6-四氟-4-(三氟甲基)溴化苯甲基 以 N,N-二甲基甲酰胺 为溶剂， 以2.04 g (85.5% yield) of 2-chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino) benzoic acid was obtained as a pale brown solid的产率得到2-chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid
  参考文献：
  名称：

  Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same

  摘要：

  本发明涉及一种四氟苯甲基衍生物及其制备方法，以及一种包含该衍生物的用于预防和治疗中枢神经系统和眼科疾病的药物组合物。本发明的四氟苯甲基衍生物可有效用于预防和治疗慢性神经退行性疾病，如阿尔茨海默病、帕金森病和亨廷顿病，退行性脑病，如癫痫和缺血性脑病，如中风。

  公开号：

  US07319160B2

文献信息

• [EN] TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME<br/>[FR] DERIVES DE TETRAFLUOROBENZYLE ET COMPOSITION PHARMACEUTIQUE POUR LA PREVENTION ET LE TRAITEMENT DE MALADIES NEURODEGENERATIVES AIGUES ET CHRONIQUES AFFECTANT LE SYSTEME NERVEUX CENTRAL CONTENANT LESDITS DERIVES
  申请人：NEUROTECH CO LTD

  公开号：WO2004000786A1

  公开（公告）日：2003-12-31

  The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative diseases in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl derivative of the present invention can effectively be used to prevent and treat chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, degenerative brain disease such as epilepsy and ischemic brain disease such as stroke.

  本发明涉及一种四氟苯基衍生物和一种药物组合物，用于预防和治疗中枢神经系统和眼科疾病的急性和慢性神经退行性疾病。本发明的四氟苯基衍生物可以有效地用于预防和治疗慢性神经退行性疾病，如阿尔茨海默病、帕金森病和亨廷顿病，以及癫痫等退化性脑病和缺血性脑病，如中风。
• Compounds and compositions for treating neuronal death or neurological dysfunction
  申请人：Gwag Joo Byoung

  公开号：US20070298129A1

  公开（公告）日：2007-12-27

  The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

  本发明涉及2-羟基-烷基氨基苯甲酸衍生物及细胞坏死抑制剂和锂的组合物，以及制备该衍生物或组合物的过程，含有该衍生物或组合物的制药配方，以及通过同时或顺序给药使用该衍生物或组合物以改善神经元死亡或神经功能障碍的治疗。本发明的衍生物和组合物对于治疗神经系统疾病，如肌萎缩侧索硬化症（ALS，路易·格里格病）、脊髓性肌萎缩症、阿尔茨海默病、帕金森病、亨廷顿病、中风、创伤性脑损伤或脊髓损伤；以及治疗眼科疾病，如青光眼、糖尿病性视网膜病变或黄斑变性有用。
• COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION
  申请人：GWAG Byoung Joo

  公开号：US20120301551A1

  公开（公告）日：2012-11-29

  The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

  本发明涉及2-羟基-烷基氨基苯甲酸衍生物以及细胞坏死抑制剂和锂的组合物，制备衍生物或组合物的方法，含有衍生物或组合物的制药配方，以及通过同时或顺序给药使用衍生物或组合物来改善神经元死亡或神经功能障碍的治疗。本发明的衍生物和组合物对于治疗神经系统疾病非常有用，例如肌萎缩性侧索硬化症（ALS，路易·格里格氏病），脊髓肌肉萎缩症，阿尔茨海默病，帕金森病，亨廷顿病，中风，创伤性脑损伤或脊髓损伤；以及治疗眼科疾病，如青光眼，糖尿病性视网膜病变或黄斑变性。
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING BURN INJURIES
  申请人：Neurotech Pharmaceuticals Co., Ltd.

  公开号：EP2417972B1

  公开（公告）日：2017-06-14
• TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME
  申请人：Neurotech Co., Ltd.

  公开号：EP1551793A1

  公开（公告）日：2005-07-13