(1S,2S)-23-(cyclopropylmethyl)-15,23-diazaheptacyclo[14.9.1.01,14.02,22.04,13.05,10.020,26]hexacosa-4(13),5,7,9,11,16,18,20(26)-octaene-2,17-diol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,2S)-23-(cyclopropylmethyl)-15,23-diazaheptacyclo[14.9.1.01,14.02,22.04,13.05,10.020,26]hexacosa-4(13),5,7,9,11,16,18,20(26)-octaene-2,17-diol
• 化学式: C₂₈H₂₈N₂O₂
• 分子量: 424.5
• InChiKey: ANAAYZYSTGIMJN-ZVAACIFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Opiate analogs selective for the delta-opioid receptor
  申请人：Welsh J. William

  公开号：US20070105884A1

  公开（公告）日：2007-05-10

  Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known μ-opioid receptor selectors as analgesics.
• US7164021B2
  申请人：——

  公开号：US7164021B2

  公开（公告）日：2007-01-16