1,1-二溴-2,2-二氟乙烷 | 359-19-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 1,1-二溴-2,2-二氟乙烷
• 英文名称: 1,1-dibromo-2,2-difluoroethane
• 英文别名: 1,1-Difluoro-2,2-dibromoethane
• CAS: 359-19-3
• 化学式: C₂H₂Br₂F₂
• 分子量: 223.843
• InChiKey: NXFKOKIVSXXVIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2903799090

反应信息

• 作为反应物：
  描述：

  1,1-二溴-2,2-二氟乙烷 在 mercury(II) fluoride 作用下， 180.0~190.0 ℃ 、980.59 kPa 条件下， 生成 1,1,2,2-四氟乙烷
  参考文献：
  名称：

  Iodine Excess and Hyperthyroidism

  摘要：

  150 mug iodine are daily required for thyroid hormone synthesis. The thyroid gland has intrinsic mechanisms that maintain normal thyroid function even in the presence of iodine excess. Large quantities of iodide are present in drugs, antiseptics, contrast media and food preservatives. Iodine induced hyperthyroidism is frequently observed in patients affected by euthyroid iodine deficient goiter when suddenly exposed to excess iodine. Possibly the presence of autonomous thyroid function permits the synthesis and release of excess quantities of thyroid hormones. The presence of thyroid autoimmunity in patients residing in iodine-insufficient areas who develop iodine-induced hyperthyroidism has not been unanimously observed. In iodine-sufficient areas, iodine-induced hyperthyroidism has been reported in euthyroid patients with previous thyroid diseases. Euthyroid patients previously treated with antithyroid drugs for Graves' disease are prone to develop iodine-induced hyperthyroidism. As well, excess iodine in hyperthyroid Graves' disease patients may reduce the effectiveness of the antithyroid drugs. Occasionally iodine-induced hyperthyroidism has been observed in euthyroid patients with a previous episode of post-partum thyroiditis, amiodarone destructive or type II thyrotoxicosis and recombinant interferon-cu induced destructive thyrotoxicosis. Amiodarone administration may induce thyrotoxicosis. Two mechanisms are responsible for this condition. One is related to excess iodine released from the drug, approximately 9 mg of iodine following a daily dose of 300 mg amiodarone. This condition is an iodine-induced thyrotoxicosis or type I amiodarone-induced thyrotoxicosis. The other mechanism is due to the amiodarone molecule that induces a destruction of the thyroid follicles with a release of preformed hormones. This condition is called amiodarone-induced destructive thyrotoxicosis or type II thyrotoxicosis. Patients developing type I thyrotoxicosis in general have preexisting nodular goiter whereas those developing type II thyrotoxicosis have a normal thyroid gland. The latter group of patients, after recovering from the destructive process, may develop permanent hypothyroidism as the consequence of fibrosis of the gland.

  DOI：

  10.1089/105072501300176453
• 作为产物：
  描述：

  1,1,2,2-四溴乙烷 在 silver(II) fluoride 作用下， 生成 1,1-二溴-2,2-二氟乙烷
  参考文献：
  名称：

  1,1,2,2-四氟乙烷及其13C2和d2同位素的合成和振动光谱

  摘要：

  已经合成了 1,1,2,2-四氟乙烷 (TFEA) 的 13C2 和 d2 同位素。这些新物种的拉曼光谱已被记录，所有三种同位素的红外光谱也已被记录，包括一些在-100°C 具有高分辨率的区域。在最近公布的频率和红外强度计算以及新光谱的指导下，我们修改了之前对 TFEA 正常物种的两个旋转异构体的基本原理的分配。提出了 13C2 和 d2 同位素异构体的两个旋转异构体的基本分配。反旋转异构体是气相中更丰富的物质，并且在较小程度上是液相中的物质，并且是晶相中的唯一物质。因此，所有三种同位素物种的反旋转异构体的分配都是完整的，并得到同位素产品规则的支持，但左旋异构体的分配不完整。提供了正常物种的左旋旋转异构体缺失频率的估计值。

  DOI：

  10.1021/jp0004967

文献信息

• Synthesis and Vibrational Spectroscopy of 1,1,2,2-Tetrafluoroethane and Its ¹³C₂ and d₂ Isotopomers
  作者：Norman C. Craig、Jessica I. Chuang、Christiana C. Nwofor、Catherine M. Oertel

  DOI：10.1021/jp0004967

  日期：2000.11.1

  previous assignments of fundamentals for the two rotamers of the normal species of TFEA. Assignments of the fundamentals for both rotamers of the 13C2 and d2 isotopomers are proposed. The anti rotamer is the more abundant species in the gas phase and, to a lesser extent, in the liquid phase and the only species in the crystal phase. Thus, the assignments of the anti rotamer of all three isotopic species are

  已经合成了 1,1,2,2-四氟乙烷 (TFEA) 的 13C2 和 d2 同位素。这些新物种的拉曼光谱已被记录，所有三种同位素的红外光谱也已被记录，包括一些在-100°C 具有高分辨率的区域。在最近公布的频率和红外强度计算以及新光谱的指导下，我们修改了之前对 TFEA 正常物种的两个旋转异构体的基本原理的分配。提出了 13C2 和 d2 同位素异构体的两个旋转异构体的基本分配。反旋转异构体是气相中更丰富的物质，并且在较小程度上是液相中的物质，并且是晶相中的唯一物质。因此，所有三种同位素物种的反旋转异构体的分配都是完整的，并得到同位素产品规则的支持，但左旋异构体的分配不完整。提供了正常物种的左旋旋转异构体缺失频率的估计值。
• Microscale Preparation of Isotopically Enriched ³⁷ClHC˭CHF
  作者：Alessandro Baldan

  DOI：10.1081/scc-120030310

  日期：2004.12.31

  Abstract Chlorination of 1‐bromo‐2‐fluoroethylene followed by reductive dehalogenation of the produced 1‐bromo‐1,2‐dichloro‐2‐fluoroethane selectively affords 1‐chloro‐2‐fluoroethylene. This process is suitable to produce 37Cl isotopically enriched ClHC˭CHF on a convenient scale (3.8 mmol).

  摘要 1-溴-2-氟乙烯氯化，然后对生成的1-溴-1,2-二氯-2-氟乙烷进行还原脱卤，选择性地得到1-氯-2-氟乙烯。该过程适用于以方便的规模 (3.8 mmol) 生产富含 37Cl 同位素的 ClHC˭CHF。
• Henne, Journal of the American Chemical Society, 1938, vol. 60, p. 1570
  作者：Henne

  DOI：——

  日期：——
• Swarts, Bulletin de la Societe Chimique de France, 1919, vol. <4>25, p. 168
  作者：Swarts

  DOI：——

  日期：——
• Boguslavskaya, L. S.; Chuvatkin, N. N.; Kartashov, A. V., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, p. 230 - 236
  作者：Boguslavskaya, L. S.、Chuvatkin, N. N.、Kartashov, A. V.、Ternovskoi, L. A.

  DOI：——

  日期：——

表征谱图