1,1-二苯基乙胺盐酸盐 | 107622-09-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1-二苯基乙胺盐酸盐
• 英文名称: 1,1-diphenylethylamine hydrochloride
• 英文别名: 1,1-diphenyl-ethylamine; hydrochloride；1,1-Diphenyl-aethylamin; Hydrochlorid；1,1-diphenylethanamine;hydrochloride
• CAS: 107622-09-3
• 化学式: C₁₄H₁₅N*ClH
• 分子量: 233.741
• InChiKey: JQDDWAJCTLVQRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.33
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  水 、 1,1-二苯基乙胺盐酸盐 生成 1,1-二苯乙烯
  参考文献：
  名称：

  Brander, Recueil des Travaux Chimiques des Pays-Bas, 1918, vol. 37, p. 83

  摘要：

  DOI：
• 作为产物：
  描述：

  phenylmagnesium bromide 、 乙腈 在 titanium(IV) isopropylate 盐酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 以57%的产率得到1,1-二苯基乙胺盐酸盐
  参考文献：
  名称：

  Addition of organometallic reagents to nitriles promoted by titanium(IV) isopropoxide as a procedure of synthesis of primary tert-alkylamines

  摘要：

  Grignard reagents are able to add twice to nitriles in the presence of titanium(IV) isopropoxide providing primary tert-alkylamines in a fair yield. The conditions and structural features of reagents required for successful reaction were established. A possibility to apply two different organometallic reagents was demonstarated, in particular, the use of organolithium compounds in the second stage.

  DOI：

  10.1134/s1070428007100016

文献信息

• [EN] TRANSACETALISATION PROCESS<br/>[FR] METHODE DE TRANSACETALISATION
  申请人：UNIV MONASH

  公开号：WO2005070911A1

  公开（公告）日：2005-08-04

  The invention relates to the resolution of racemic mixtures, and in particular to the separation of enantiomers of chiral alcohols utilising recyclable chiral auxiliaries. The present invention also relates to a process for preparing these recyclable chiral auxiliaries using an enantiomerically pure alcohol.

  这项发明涉及手性混合物的分离，特别是利用可回收手性辅助剂分离手性醇的对映体。本发明还涉及利用对映纯醇制备这些可回收手性辅助剂的方法。
• Compounds for Control of Appetite
  申请人：Balasubramaniam Ambikaipakan

  公开号：US20080221038A1

  公开（公告）日：2008-09-11

  This invention relates generally to peptides including tripeptides and to methods for pharmaceutical treatment of mammals using such tripeptides and analogs thereof. More specifically, the invention is directed to neuropeptide Y (“NPY”) receptor antagonists and agonists including O-glycosylated tripeptides, i.e. O-glycopeptides, and extended tripeptides, and their analogs, as well as to PYY analogs, to pharmaceutical compositions containing such tripeptides and PYY analogs, and to methods of treatment of mammals using such tripeptides and PYY analogs. In addition, the invention relates to methods of treatment of mammals using such tripeptides and PYY analogs for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.

  这项发明涉及一般的肽包括三肽以及使用这些三肽及其类似物对哺乳动物进行药物治疗的方法。更具体地，该发明涉及神经肽Y（“NPY”）受体拮抗剂和激动剂，包括O-糖基化三肽，即O-糖肽，以及扩展三肽及其类似物，以及PYY类似物，包括含有这些三肽和PYY类似物的药物组合物，以及使用这些三肽和PYY类似物对哺乳动物进行治疗的方法。此外，该发明涉及使用这些三肽和PYY类似物进行治疗的方法，用于控制食欲、血压、心血管反应、性欲和昼夜节律。
• METHODS AND REAGENTS FOR DETERMINING ENZYME SUBSTRATE SPECIFICITY, AND USES RELATED THERETO
  申请人：TRUSTEES OF TUFTS COLLEGE

  公开号：EP1169470A1

  公开（公告）日：2002-01-09
• BICYCLIC HYDANTOIN DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF
  申请人：LION Bioscience AG

  公开号：EP1301512A2

  公开（公告）日：2003-04-16
• Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
  申请人：University of Cincinnati

  公开号：US20040209820A1

  公开（公告）日：2004-10-21

  This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compositions containing such dipeptides and tripeptides and to methods of treatment of mammals using such dipeptides and tripeptides. In addition, the invention relates to methods of treatment of mammals using such dipeptides and tripeptides for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.