2-chloro-4-chlorodifluoromethoxynitrobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-4-chlorodifluoromethoxynitrobenzene
• 英文别名: 2-Chloro-4-[chloro(difluoro)methoxy]-1-nitrobenzene
• 化学式: C₇H₃Cl₂F₂NO₃
• 分子量: 258.009
• InChiKey: WBGITGWDHZKGBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-chloro-4-chlorodifluoromethoxynitrobenzene 在 氢氟酸 作用下， 125.0 ℃ 、1.62 MPa 条件下， 反应 40.0h， 以26%的产率得到2-氯-4-三氟甲氧基硝基苯
  参考文献：
  名称：

  A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides

  摘要：

  Enolized 1,3-dioxane-4,6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A(2) from human polymorphonuclear leucocytes (h-PMN PLA(2)). Among the more than 30 compounds synthesized, the most potent inhibitors (IC50 0.6-10 mu M) were found in the series of 2,4-disubstituted phenyl analogues of a. Compound 1a was selected for evaluation of its biological profile. This substance potently inhibited secretory PLA(2)s from several sources other than human PMNs, with a clear preference for group II over group I PLA(2), whereas human cytosolic PLA(2) and phospholipase C were not significantly affected. Inhibition of h-PMN PLA(2) was calcium-dependent. In intact mammalian cells stimulated in vitro, the release of arachidonic acid and the generation of prostaglandins and leukotrienes were inhibited at concentrations compatible with inhibition of PLA(2) as an underlying mechanism. In animal models in vivo (carragheenan oedema, adjuvant arthritis, pertussis pleurisy) 1a showed antiinflammatory activity, although the effect was rather weak compared with standard reference compounds.

  DOI：

  10.1016/0223-5234(94)90026-4
• 作为产物：
  描述：

  3-氯-4-硝基苯酚 、 氯甲酸三氯甲酯 在 氢氟酸 作用下， 生成 2-chloro-4-chlorodifluoromethoxynitrobenzene
  参考文献：
  名称：

  A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides

  摘要：

  Enolized 1,3-dioxane-4,6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A(2) from human polymorphonuclear leucocytes (h-PMN PLA(2)). Among the more than 30 compounds synthesized, the most potent inhibitors (IC50 0.6-10 mu M) were found in the series of 2,4-disubstituted phenyl analogues of a. Compound 1a was selected for evaluation of its biological profile. This substance potently inhibited secretory PLA(2)s from several sources other than human PMNs, with a clear preference for group II over group I PLA(2), whereas human cytosolic PLA(2) and phospholipase C were not significantly affected. Inhibition of h-PMN PLA(2) was calcium-dependent. In intact mammalian cells stimulated in vitro, the release of arachidonic acid and the generation of prostaglandins and leukotrienes were inhibited at concentrations compatible with inhibition of PLA(2) as an underlying mechanism. In animal models in vivo (carragheenan oedema, adjuvant arthritis, pertussis pleurisy) 1a showed antiinflammatory activity, although the effect was rather weak compared with standard reference compounds.

  DOI：

  10.1016/0223-5234(94)90026-4

文献信息

• Haloalkoxy-substituted diphenyl ethers; their use as herbicides and in herbicidal compositions and processes of making them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0063873A1

  公开（公告）日：1982-11-03

  Compounds of the formula (I) wherein R' is C1-C2 haloalkyl containing F or Cl, X and Y are H, halogen, alkyl, CN, NO, or CF3; A is H, CH3, NO2, halogen, CN or CF3; and R2 is (a) -OH (b) -OM wherein M is a cation; (c) -OR3 wherein R3 is optionally substituted phenyl, alkyl, alkenyl or alkynyl (d) -NR4R5 wherein each group R4 and R5 is hydrogen or optionally substituted alkyl, alkenyl or phenyl or (e) -NHSO2R3 or -NMSO2R3. The compounds are useful as herbicides.

  式 (I) 的化合物 其中 R' 是含 F 或 Cl 的 C1-C2 卤代烷基，X 和 Y 是 H、卤素、烷基、CN、NO 或 CF3；A 是 H、CH3、NO2、卤素、CN 或 ；R2 是 (a) -OH (b) -OM 其中 M 是阳离子；(c) -OR3 其中 R3 是任选取代的苯基、烷基、烯基或炔基 (d) -NR4R5 其中每个基团 R4 和 R5 是氢或任选取代的烷基、烯基或苯基或 (e) -NHSO2R3 或 -NMSO2R3。 这些化合物可用作除草剂。