1,2-二(4-溴苯基)-1-(3-硫代-3H-1,2,4-二噻唑-5-基)胍 | 151220-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,2-二(4-溴苯基)-1-(3-硫代-3H-1,2,4-二噻唑-5-基)胍
• 英文名称: N,N'-Bis-(4-bromo-phenyl)-N-(5-thioxo-5H-[1,2,4]dithiazol-3-yl)-guanidine
• 英文别名: N',N'-Bis(4-bromophenyl)-N-(3-thioxo-3H-1,2,4-dithiazol-5-yl)guanidine；1,2-bis(4-bromophenyl)-1-(5-sulfanylidene-1,2,4-dithiazol-3-yl)guanidine
• CAS: 151220-60-9
• 化学式: C₁₅H₁₀Br₂N₄S₃
• 分子量: 502.277
• InChiKey: QGBAIRDRCHHLKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硫化碳 、 (4-bromo-phenyl)-[4-(4-bromo-phenyl)-5-imino-4,5-dihydro-[1,2,4]thiadiazol-3-yl]-amine 以 乙醇 为溶剂， 反应 4.0h， 以65%的产率得到1,2-二(4-溴苯基)-1-(3-硫代-3H-1,2,4-二噻唑-5-基)胍
  参考文献：
  名称：

  3-Thio-5-(N-aryl-N′-arylguanyl)-1,2,4-dithiazoles as potential anti-convulsant and analgesic agents

  摘要：

  The synthesis and biological activities of a number of substituted 3-thio-5-(N-aryl-N'-arylguanyl)-1,2,4-dithiazoles are reported. The aromatic substitutents m-CH3 3, p-CH3 4 and p-bromo 11 produced compounds with potent anti-convulsant properties in rats and compared favorably with the standard anti-convulsant drugs phenytoin and phenobarbitone-sodium in a number of test situations. In the analgesic test, most of the compounds exhibited analgesic activity with particular reference to p-CH3 4 substitution being most potent in the series.

  DOI：

  10.1016/0223-5234(93)90010-c

文献信息

• 3-Thio-5-(N-aryl-N′-arylguanyl)-1,2,4-dithiazoles as potential anti-convulsant and analgesic agents
  作者：K Srivastava、SN Pandeya

  DOI：10.1016/0223-5234(93)90010-c

  日期：1993.1

  The synthesis and biological activities of a number of substituted 3-thio-5-(N-aryl-N'-arylguanyl)-1,2,4-dithiazoles are reported. The aromatic substitutents m-CH3 3, p-CH3 4 and p-bromo 11 produced compounds with potent anti-convulsant properties in rats and compared favorably with the standard anti-convulsant drugs phenytoin and phenobarbitone-sodium in a number of test situations. In the analgesic test, most of the compounds exhibited analgesic activity with particular reference to p-CH3 4 substitution being most potent in the series.