1,2-二(4-羟基苯)-1,2-二苯乙烯 | 80232-65-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1,2-二(4-羟基苯)-1,2-二苯乙烯
• 英文名称: 4,4′-(1,2-diphenylethene-1,2-diyl)diphenol
• 英文别名: (E)-4,4'-(1,2-diphenylethene-1,2-diyl)diphenol；4,4'-(1,2-Diphenylethene-1,2-diyl)diphenol；4-[(E)-2-(4-hydroxyphenyl)-1,2-diphenylethenyl]phenol
• CAS: 80232-65-1
• 化学式: C₂₆H₂₀O₂
• 分子量: 364.444
• InChiKey: ZYIGFXHZSKIVOO-OCEACIFDSA-N

物化性质

• 沸点：
  488.8±40.0 °C(Predicted)
• 密度：
  1.205±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-二(4-羟基苯)-1,2-二苯乙烯 在 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 1.0h， 生成 1-[2-[4-[(E)-2-[4-(2-imidazol-1-ylethoxy)phenyl]-1,2-diphenylethenyl]phenoxy]ethyl]imidazole
  参考文献：
  名称：

  Imidazole-bearing tetraphenylethylene: fluorescent probe for metal ions based on AIE feature

  摘要：

  在四氢呋喃-水混合物中，含咪唑的四苯基乙烯悬浮液具有聚集诱发的发射特征，水份含量高，发射率高，由于咪唑分子与 Fe3+ 离子之间的配位，Fe3+ 离子可以完全淬灭咪唑。

  DOI：

  10.1039/c1nj20122k
• 作为产物：
  描述：

  4-羟基-二苯甲酮 在 四氯化钛 、 锌 作用下， 以 四氢呋喃 为溶剂， 生成 1,2-二(4-羟基苯)-1,2-二苯乙烯
  参考文献：
  名称：

  Monomeric and aggregation emissions of tetraphenylethene in a photo-switchable polymer controlled by cyclization of diarylethene and solvent conditions

  摘要：

  在高含水量条件下，研究了具有DAE开放和闭合形式的TPE在光开关聚合物中的AIE行为。

  DOI：

  10.1039/c7tc03071a

文献信息

• WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN
  申请人：TANG Benzhong

  公开号：US20120172296A1

  公开（公告）日：2012-07-05

  The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.

  目前描述的主题涉及水溶性共轭聚烯烃化合物及其衍生物，这些化合物表现出聚集诱导发光，以及任何水分散的荧光聚合微粒、纳米粒子和/或含有水溶性共轭聚烯烃化合物和/或其衍生物的药物组合物。还提供了制备和使用目前描述的主题的化合物、衍生物和颗粒的方法。目前描述的水溶性共轭聚烯烃化合物可用作生物探针，用于检测生物大分子，在传感器的制造中，用于监测和延缓体外和体内淀粉样蛋白纤维的形成，以及用于开发抗癌药物。
• AIE-induced fluorescent vesicles containing amphiphilic binding pockets and the FRET triggered by host–guest chemistry
  作者：Meng Zhang、Xianpeng Yin、Tian Tian、Yun Liang、Weina Li、Yue Lan、Jian Li、Meimei Zhou、Yong Ju、Guangtao Li

  DOI：10.1039/c5cc02377g

  日期：——

  Synergetic combination of TPE and bile acid units could directly afford uniform fluorescent vesicles with amphiphilic binding sites.

  TPE和胆酸单元的协同组合可以直接产生具有两性结合位点的均匀荧光囊泡。
• Fluorescent water-soluble conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same
  申请人：Tang Benzhong

  公开号：US20080220407A1

  公开（公告）日：2008-09-11

  The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conjugated polyene compounds. Also provided are methods of making and using the compounds and particles. The described conjugated polyene compounds are useful as bioprobes for the detection biomacromolecules, as well as in the manufacture of sensors.

  目前所描述的主题涉及具有聚集诱导发光性质的水溶性共轭聚烯烃化合物，以及包含这些水溶性共轭聚烯烃化合物的水分散荧光聚合微粒和/或纳米粒子。还提供了制备和使用这些化合物和微粒子的方法。所述的共轭聚烯烃化合物可用作检测生物大分子的生物探针，以及制造传感器的材料。
• Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same
  申请人：Tang Benzhong

  公开号：US20100009362A1

  公开（公告）日：2010-01-14

  The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conjugated polyene compounds. Also provided are methods of making and using the compounds and particles. The described conjugated polyene compounds are useful as bioprobes for the detection biomacromolecules, as well as in the manufacture of sensors.

  目前所描述的主题涉及水溶性共轭聚烯化合物，其表现出聚集诱导发光，以及包含水溶性共轭聚烯化合物的水分散性荧光聚合微粒和/或纳米粒子。还提供了制备和使用化合物和微粒子的方法。所述的共轭聚烯化合物可用作检测生物大分子的生物探针，以及制造传感器的用途。
• AGGREGATION INDUCED EMISSION OF FLUORESCENT BIOPROBES AND METHODS OF USING THE SAME
  申请人：Technology The Hong Kong University of Science And

  公开号：US20130266953A1

  公开（公告）日：2013-10-10

  Provided herein are fluorescent bioprobes comprising fluorogens that exhibit aggregation-induced emission (AIE) labeled on biomolecules. The present subject matter relates to a fluorescent bioprobe comprising one or more fluorogen labeled on chitosan. The present subject matter is also directed to methods of preparing the fluorescent bioprobes, methods of labeling and detecting DNA and/or proteins with the fluorescent bioprobe, and methods of cell imaging including live cell tracking.

  本文提供了一种荧光生物探针，其中包含标记在生物分子上的聚集诱导发光（AIE）荧光原料。本文所述主题涉及一种荧光生物探针，其中包括在壳聚糖上标记的一种或多种荧光原料。本文所述主题还涉及制备荧光生物探针的方法，使用荧光生物探针标记和检测DNA和/或蛋白质的方法，以及细胞成像的方法，包括活细胞跟踪。