11-[2-(4-Methylpiperazin-1-yl)acetyl]-5,11-dihydropyrido[3,2-c][2]benzazepin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 11-[2-(4-Methylpiperazin-1-yl)acetyl]-5,11-dihydropyrido[3,2-c][2]benzazepin-6-one
• 化学式: C₂₀H₂₂N₄O₂
• 分子量: 350.4
• InChiKey: NRMLXVYJFZROOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PIRENZEPINE AND DERIVATIVES THEREOF AS ANTI-AMYLOID AGENTS
  申请人：Pfeifer Andrea

  公开号：US20100247688A1

  公开（公告）日：2010-09-30

  The present invention relates to a compound that is capable of inhibiting the formation of β-amyloid plaques, of reducing and/or retarding the increase the β-amyloid plaque load in the brain of an animal, particularly a mammal, but especially a human. In particular, the invention relates to compounds of formula (I) and to metabolites thereof.