N-[(E)-(4-bromophenyl)methylideneamino]-5-(4-nitrophenyl)pyrimidin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[(E)-(4-bromophenyl)methylideneamino]-5-(4-nitrophenyl)pyrimidin-2-amine
• 化学式: C17H12BrN5O2
• 分子量: 398.2
• InChiKey: SJGWNTJXPCRXCW-ZVBGSRNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] INHIBITORS TO TARGET HIV-1 NEF-CD80/CD86 INTERACTIONS FOR THERAPEUTIC INTERVENTION<br/>[FR] INHIBITEURS DESTINÉS À CIBLER DES INTERACTIONS NEF-CD80/CD86 DU VIH-1 POUR UNE INTERVENTION THÉRAPEUTIQUE
  申请人：NAT CENTRE FOR BIOLOGICAL SCIENCES TIFR

  公开号：WO2020035880A1

  公开（公告）日：2020-02-20

  The compounds of Formula I, II, and III along with their stereoisomers, pharmaceutically acceptable salts, polymorphs, solvates and hydrates thereof are described in the present disclosure. The said compounds restore immune activation in case of infections or a disease associated with an HIV infection in a subject in need thereof.

  公式I、II和III的化合物及其立体异构体、药学上可接受的盐、多型体、溶剂合物和水合物在本公开中有所描述。所述化合物可在需要的受试者中恢复免疫激活，以应对感染或与HIV感染相关的疾病。
• INHIBITORS TO TARGET HIV-1 NEF-CD80/CD86 INTERACTIONS FOR THERAPEUTIC INTERVENTION
  申请人：NATIONAL CENTRE FOR BIOLOGICAL SCIENCES-TIFR

  公开号：US20220062281A1

  公开（公告）日：2022-03-03

  The compounds of Formula I, II, and III along with their stereoisomers, pharmaceutically acceptable salts, polymorphs, solvates and hydrates thereof are described in the present disclosure. The said compounds restore immune activation in case of infections or a disease associated with an HIV infection in a subject in need thereof.