1,2-萘醌-4-磺酸钾盐 | 5908-27-0

• 物质功能分类: 化学试剂 - 有机试剂 - 双环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1,2-萘醌-4-磺酸钾盐
• 中文别名: 1,2-萘醌-4-磺酸钾
• CAS: 5908-27-0
• 化学式: C10H6KO5S
• 分子量: 277.32
• InChiKey: UNZQHCMHYSYLOA-UHFFFAOYSA-N

物化性质

• 熔点：
  286-288 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.9
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S22,S26,S37,S39
• 危险类别码：
  R36/37/38

制备方法与用途

化学性质
金黄色针状结晶。90%产品的熔点为286-288℃。该物质能溶于50%的醇中，微溶于水，溶液呈弱碱性。其钠盐（[521-24-4]）易溶于水，微溶于95%乙醇。

用途
主要用于染料中间体。钠盐还用于比色测定胺类、氨基酸和磺胺衍生物。

生产方法
通过将1-氨基-2-萘酚-4-磺酸用稀硝酸氧化得到产物，该过程放出的二氧化氮使产物呈橙黄色。随后加入饱和氯化铵溶液生成1,2-萘醌-4-磺酸铵。再将其溶于含溴的水中，并用活性炭脱色处理，最终加饱和氯化钾析出钾盐结晶，收率约为17-18%。

文献信息

• METHOD OF DETECTING INORGANIC PHOSPHORIC ACID, PYROPHOSPHORIC ACID AND NUCLEIC ACID AND METHOD OF TYPING SNP SEQUENCE OF DNA
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP1378575A1

  公开（公告）日：2004-01-07

  According to the present invention, an inorganic phosphoric acid is detected by a method which includes: a step of subjecting a sample to a measurement system containing glyceraldehyde-3-phosphate, oxidized nicotinamide adenine dinucleotide or oxidized nicotinamide adenine dinucleotide phosphate, glyceraldehyde phosphate dehydrogenase, and an electron mediator; and a step of measuring a current value in the measurement system. In the method, a pyrophosphate is quantitatively measured with high sensitivity and at a high speed through converting the pyrophosphate in a sample into an inorganic phosphoric acid. Such a measurement of a pyrophosphate allows for quantitative determination of the pyrophosphate which is produced concurrent with the extension of a DNA, thereby enabling the detection of the presence of a targeted nucleic acid, and typing of a base in a SNP site of a targeted DNA.

  根据本发明，无机磷酸的检测方法包括：将样品置于含有 3-磷酸甘油醛、氧化烟酰胺腺嘌呤二核苷酸或氧化烟酰胺腺嘌呤二核苷酸磷酸酯、磷酸甘油醛脱氢酶和电子介质的测量系统中；以及测量测量系统中的电流值。在该方法中，通过将样品中的焦磷酸转化为无机磷酸，以高灵敏度和高速度定量测量焦磷酸。通过这种焦磷酸测量方法，可以定量测定 DNA 延伸过程中产生的焦磷酸，从而检测目标核酸的存在，并对目标 DNA SNP 位点中的碱基进行分型。
• Method of detecting inorganic phosphoric acid, pyrophosphate and nucleic acid, and method of typing SNP sequence of DNA
  申请人：Matsushita Electric Industrial Co., Ltd.

  公开号：US20040171100A1

  公开（公告）日：2004-09-02

  According to the present invention, an inorganic phosphoric acid is detected by a method which includes: subjecting a sample to a measurement system containing glyceraldehyde-3-phosphate, oxidized nicotinamide adenine dinucleotide or oxidized nicotinamide adenine dinucleotide phosphate, glyceraldehyde phosphate dehydrogenase, and an electron mediator; and measuring a current value in the measurement system. In the method, a pyrophosphate is quantitatively measured with high sensitivity and at a high speed through converting the pyrophosphate in a sample into an inorganic phosphoric acid. Such a measurement of a pyrophosphate allows for quantitative determination of the pyrophosphate which is produced concurrent with the extension of a DNA, thereby enabling the detection of the presence of a targeted nucleic acid, and typing of a base in a SNP site of a targeted DNA.

  根据本发明，无机磷酸的检测方法包括：将样品置于含有 3-磷酸甘油醛、氧化烟酰胺腺嘌呤二核苷酸或氧化烟酰胺腺嘌呤二核苷酸磷酸酯、磷酸甘油醛脱氢酶和电子介质的测量系统中；测量测量系统中的电流值。在该方法中，通过将样品中的焦磷酸转化为无机磷酸，可以高灵敏度和高速度地定量测量焦磷酸。通过这种焦磷酸测量方法，可以定量测定 DNA 延伸过程中产生的焦磷酸，从而检测目标核酸的存在，并对目标 DNA SNP 位点中的碱基进行分型。
• Cholesterol sensor
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP0794429B1

  公开（公告）日：2002-07-31
• IMMUNOASSAY DEVICE AND METHOD
  申请人：Hayashi Yoko

  公开号：US20090246795A1

  公开（公告）日：2009-10-01

  An immunoassay device capable of assaying amount of an antigen by allowing a labeled antibody to specifically bind to a antigen analyte in a sample and assaying a label of a bound product, an interior of a single device has four regions comprises: (1) a first region where the antigen in the sample reacts with a first antibody that is the labeled antibody capable of specifically binding to the antigen, (2) a second region where first antibody that has not bound to the antigen reacts with a second biotin- or avidin-bound antibody, (3) a third region where, depending on whether the second antibody is biotin-bound antibody or avidin-bound antibody, either avidin or biotin is immobilized by immobilization means so as to be unable to move to the fourth region, and the second antibody is captured by the immobilized avidin or biotin, and (4) a fourth region where the label of the first antibody that has bound to the antigen is detected, being constructed in such a way that a solution can move sequentially through each region, the first antibody, which is the labeled antibody such that an antibody component is an F(ab′) fragment or reduced IgG, the F(ab′) fragment or reduced IgG being bound with the label in a predetermined proportion, is included in the first region or an adjacent region, and the second antibody is a biotin- or avidin-bound antibody, being of anti-idiotype antibody against the first antibody and a type that cannot bind to the bound product of the antigen and first antibody, and is included in the second region or an adjacent region.
• US5684035A
  申请人：——

  公开号：US5684035A

  公开（公告）日：1997-11-04