1,3,6-三磺酰基芘8-异硫氰酸酯 | 58226-67-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: 1,3,6-三磺酰基芘8-异硫氰酸酯
• 英文名称: 1,3,6-Trisulfonylpyrene 8-isothiocyanate
• 英文别名: 8-isothiocyanatopyrene-1,3,6-trisulfonic acid
• CAS: 58226-67-8
• 化学式: C₁₇H₉NO₉S₄
• 分子量: 499.5
• InChiKey: HVTTVIRJVMCXFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  233
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Contrast Agents
  申请人：Lovhaug Dagfinn

  公开号：US20090208412A1

  公开（公告）日：2009-08-20

  A contrast agent of the general formula (I): Z 1 -L-V-Z 2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding affinity for areas of collagen formation, L is a covalent bond, a biomodifier or a linker moiety.

  一种通式(I)的对比剂：Z1-L-V-Z2(I)，其中至少有一个Z1和Z2存在且相等或不同，它们是可以在人或动物体内成像检测到的报告者基团，V是具有对胶原形成区域结合亲和力的靶向基团，L是共价键，生物修饰剂或连接基团。
• Contrast agents to target extracellular matrix
  申请人：GE HEALTHCARE AS

  公开号：EP2243496A2

  公开（公告）日：2010-10-27

  A contrast agent of the general formula (I):          Z1-L-V-Z2     (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding affinity for areas of collagen formation, L is a covalent bond, a biomodifier or a linker moiety.

  通式(I)的造影剂： Z1-L-V-Z2 (I) 其中，Z1 和 Z2 中至少有一个是在人体或动物体内成像时可检测到的相同或不同的报告分子，V 是对胶原形成区域具有结合亲和力的靶向分子，L 是共价键、生物调节剂或连接分子。
• Pyrenyloxysulfonic acid fluorescent agents
  申请人：Haugland Richard

  公开号：US20050123935A1

  公开（公告）日：2005-06-09

  The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.

  本发明提供了一类基于芘磺酸核的新型活性荧光剂。通过使活性基团与共轭物中其他物质上具有互补反应性的基团反应，这些制剂很容易与其他物质结合成共轭物。此外，还提供了使用本发明化合物检测和/或量化样品中分析物的方法。在一个示例性实施方案中，本发明提供了包含本发明化合物的多色检测方法。
• CONTRAST AGENTS TO TARGET EXTRACELLULAR MATRIX
  申请人：GE HEALTHCARE AS

  公开号：EP1814598B1

  公开（公告）日：2011-01-12
• PYRENYLOXYSULFONIC ACID FLURESCENT AGENTS
  申请人：Haugland Richard

  公开号：US20080032379A1

  公开（公告）日：2008-02-07

  The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.