1,3-丙烷二基二(2-羟基苯甲酸酯) | 84370-82-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,3-丙烷二基二(2-羟基苯甲酸酯)
• 英文名称: 1,3-bis-salicyloyloxy-propane
• 英文别名: 1,3-Bis-salicyloyloxy-propan；1.3-Disalicyloyloxy-propan；1,3-propanediyl disalicylate；1,3-propanediyl bissalicylate；3-(2-hydroxybenzoyl)oxypropyl 2-hydroxybenzoate
• CAS: 84370-82-1
• 化学式: C₁₇H₁₆O₆
• 分子量: 316.31
• InChiKey: RXRCNOIPYFJQPE-UHFFFAOYSA-N

物化性质

• 熔点：
  77 °C
• 沸点：
  466.4±30.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,3-二溴丙烷 、 水杨酸 在 三乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 24.33h， 以85%的产率得到1,3-丙烷二基二(2-羟基苯甲酸酯)
  参考文献：
  名称：

  High molecular wegiht polymers, devices and method for making and using same

  摘要：

  无水酐聚合物释放活性或可激活的药剂，具有预选特性，如分子量、柔韧性、硬度、粘附性等其他有价值的特性。这些聚合物适用于在一段时间内控制释放药剂的组合物、配方、涂层、设备等，这些产品受益于药剂的控制释放。这些聚合物是通过涉及各种替代和连续步骤的过程制备的，这些步骤允许事先设计具有特定特性的产品。这些聚合物适合作为传递系统，可以单独使用，也可以作为组合物、配方或设备。

  公开号：

  US20050048121A1

文献信息

• Compositions and methods for the inhibition of bone growth and resorption
  申请人：Uhrich E. Kathryn

  公开号：US20050249697A1

  公开（公告）日：2005-11-10

  A composition, or article for inhibition of bone growth and resorption comprises an anti-inflammatory agent(s), optionally other agents and carriers, monomer(s), oligomer(s), polymer(s), salt(s), mixtures(s), dispersion(s) and/or blend(s) thereof, which composition, device, or implant upon polymer erosion releases a bone growth and/or bone resorption retarding, reducing or inhibiting amount of the agent(s). The monomers, oligomers and polymers, releasing active or activatable agent(s), have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The monomers, oligomers and polymers may be prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The composition, device, implant or dressing of this patent are suitable for retarding, reducing or inhibiting bone growth or bone resorption, comprising administering or applying to a subject's pre-selected site a bone growth or resorption reducing amount of the agent(s).

  一种用于抑制骨生长和吸收的组合物或文章包括抗炎剂、可选的其他剂和载体、单体、寡聚体、聚合物、盐、混合物、分散剂和/或其混合物，该组合物、装置或植入物在聚合物侵蚀时释放出抑制、减少或抑制骨生长和/或骨吸收的剂量的药物。释放活性或可激活药物的单体、寡聚体和聚合物具有预选的性质，如分子量、柔韧性、硬度、粘附性和其他有价值的性质。可以通过涉及各种可选和连续步骤的过程来制备单体、寡聚体和聚合物，从而允许事先设计具有特定特性的产品。该专利的组合物、装置、植入物或敷料适用于减缓、减少或抑制骨生长或骨吸收，包括向受试者的预选部位施用或应用抑制骨生长或吸收的药物。
• HIGH MOLECULAR WEIGHT POLYMERS, DEVICES AND METHOD FOR MAKING AND USING SAME
  申请人：East Anthony

  公开号：US20100152410A1

  公开（公告）日：2010-06-17

  Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.

  无水酐聚合物可以释放活性或可激活的药剂，具有预选的性质，如分子量、柔韧性、硬度、粘附性和其他有价值的性质。这些聚合物适用于需要在一段时间内控制释放药剂的组合物、配方、涂层、装置等。这些聚合物是通过涉及各种替代和顺序步骤的过程制备的，允许事先设计具有特定特性的产品。这些聚合物适用于作为传递系统，可以作为组合物、配方或装置本身。
• High molecular weight polymers, devices and method for making and using same
  申请人：Rutgers, The State University of New Jersey

  公开号：US08232322B2

  公开（公告）日：2012-07-31

  Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.

  无水酐聚合物可以释放活性或可活化剂，具有预先选择的分子量、柔韧性、硬度、粘附性和其他有价值的特性。这些聚合物适用于需要在一段时间内控制释放剂量的组成物、配方、涂层、设备等。该聚合物是通过涉及各种替代和顺序步骤的过程制备的，这些步骤允许事先设计具有特定特性的产品。该聚合物适用于作为传递系统，可以作为组成物、配方或设备本身。
• Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
  申请人：Rutgers, The State University of New Jersey

  公开号：US07662864B2

  公开（公告）日：2010-02-16

  Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.

  无水酐聚合物可以释放活性或可激活的剂量，具有预选的性质，如分子量、柔韧性、硬度、粘附性和其他有价值的特性。这些聚合物适用于需要在一定时间内控制释放剂量的组合物、配方、涂层、装置等。聚合物是通过涉及各种替代和顺序步骤的过程制备的，允许事先设计具有特定特性的产品。这些聚合物适用于作为输送系统，可以单独使用，也可以作为组合物、配方或装置。
• Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria
  作者：Olga V. Tsepaeva、Taliya I. Salikhova、Leysan R. Grigor’eva、Denis V. Ponomaryov、Trinh Dang、Rezeda A. Ishkaeva、Timur I. Abdullin、Andrey V. Nemtarev、Vladimir F. Mironov

  DOI：10.1007/s00044-020-02674-6

  日期：2021.4