1,3-二(苯基)-1-(苯基甲基)硫脲 | 3053-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,3-二(苯基)-1-(苯基甲基)硫脲
• 英文名称: 1-Benzyl-1,3-diphenyl-thioharnstoff
• 英文别名: N-Benzyl-N,N'-diphenylthiocarbamid；N,N'-Diphenyl-N-benzyl-thioharnstoff；N-benzyl-N,N'-diphenyl-thiourea；N-Benzyl-N,N'-diphenyl-thioharnstoff；Carbanilide, N-benzylthio-；1-benzyl-1,3-diphenylthiourea
• CAS: 3053-39-2
• 化学式: C₂₀H₁₈N₂S
• 分子量: 318.442
• InChiKey: ZDBPEGOAAIRGTO-UHFFFAOYSA-N

物化性质

• 熔点：
  107 °C
• 沸点：
  462.1±38.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  1,3-二(苯基)-1-(苯基甲基)硫脲 在 银 作用下， 生成 N-benzyl-N,N'-diphenyl-thiourea; silver (I)-compound
  参考文献：
  名称：

  PUBOVAGINAL SLING: 4-YEAR OUTCOME ANALYSIS AND QUALITY OF LIFE ASSESSMENT

  摘要：

  Purpose: Stress urinary incontinence is a common disease with a devastating impact on patient quality of life. Needle suspension procedures, which produce disappointing long-term results for type II stress incontinence, are being replaced by pubovaginal slings which previously were reserved solely for the treatment of type III stress incontinence. We report the long-term outcomes of pubovaginal slings for the treatment of types II and III stress urinary incontinence, and assess its quality of life impact.Materials and Methods: From January 1993 until December 1996, 247 females 10 to 84 years old (mean age 54.5) with type II (54%) or III (46%) stress urinary incontinence diagnosed by fluoroscopic urodynamics received a pubovaginal sling. Concomitant urge incontinence was present in 109 patients (44%). Quality of life was assessed with the Urogenital Distress Inventory short form.Results: At a mean followup of 51 months (range 22 to 68) the continence rates were 88% overall, 91% for type II and 84% for type III. Preoperative urge incontinence resolved in 81 of 109 patients (74%), while de novo urge incontinence developed in 10 (7%). Intermittent urethral catheterization duration averaged 8.4 days, with 5 women undergoing urethrolysis for a hyper-suspended urethra. Secondary procedures were required in 9 patients with type II and 5 with type III incontinence, and included transurethral collagen injections in 6 and repeat pubovaginal slings in 8. There was a 4% complication rate due to pelvic hematoma in 2 cases, incisional hernia in 2, deep venous thrombosis in 1 and pulmonary embolus in 1. Of the 247 patients 235 (95%) completed the quality of life questionnaire with 92% reporting a high degree of satisfaction with low (less than 20 of 100 points) symptom distress scores.Conclusions: Pubovaginal slings are effective and durable, and significantly improve quality of life in patients with types II and III stress urinary incontinence.

  DOI：

  10.1016/s0022-5347(05)67557-x
• 作为产物：
  描述：

  苯甲基苯胺 、 硫代异氰酸苯酯 以 乙醇 为溶剂， 以27%的产率得到1,3-二(苯基)-1-(苯基甲基)硫脲
  参考文献：
  名称：

  Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C–N Bond Cleavage

  摘要：

  标题：摘要 钯催化的Hiyama偶联活性硫脲通过选择性C-N键断裂报道。值得注意的是，新方法利用活性硫脲作为偶联试剂，与芳基硅烷在场合中，产率良好地生成酰胺。此外，该策略利用CuF2作为关键氧化剂和活化剂，在温和条件下提供各种酰胺产品，并采用易于操作的程序，无需额外的碱。

  DOI：

  10.1055/s-0040-1720907

文献信息

• Busch; Ulmer, Chemische Berichte, 1902, vol. 35, p. 1718
  作者：Busch、Ulmer

  DOI：——

  日期：——
• Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C–N Bond Cleavage
  作者：Zhuo Zeng、Zhanyu He、Chu Yan、Mei Zhang、Majeed Irfan、Zijia Wang

  DOI：10.1055/s-0040-1720907

  日期：2022.2

  Palladium-catalyzed Hiyama coupling of active thioureas via selective C–N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF2 as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

  标题：摘要 钯催化的Hiyama偶联活性硫脲通过选择性C-N键断裂报道。值得注意的是，新方法利用活性硫脲作为偶联试剂，与芳基硅烷在场合中，产率良好地生成酰胺。此外，该策略利用CuF2作为关键氧化剂和活化剂，在温和条件下提供各种酰胺产品，并采用易于操作的程序，无需额外的碱。
• PUBOVAGINAL SLING: 4-YEAR OUTCOME ANALYSIS AND QUALITY OF LIFE ASSESSMENT
  作者：TED O. MORGAN、O. LENAINE WESTNEY、EDWARD J. McGUIRE

  DOI：10.1016/s0022-5347(05)67557-x

  日期：2000.6

  Purpose: Stress urinary incontinence is a common disease with a devastating impact on patient quality of life. Needle suspension procedures, which produce disappointing long-term results for type II stress incontinence, are being replaced by pubovaginal slings which previously were reserved solely for the treatment of type III stress incontinence. We report the long-term outcomes of pubovaginal slings for the treatment of types II and III stress urinary incontinence, and assess its quality of life impact.Materials and Methods: From January 1993 until December 1996, 247 females 10 to 84 years old (mean age 54.5) with type II (54%) or III (46%) stress urinary incontinence diagnosed by fluoroscopic urodynamics received a pubovaginal sling. Concomitant urge incontinence was present in 109 patients (44%). Quality of life was assessed with the Urogenital Distress Inventory short form.Results: At a mean followup of 51 months (range 22 to 68) the continence rates were 88% overall, 91% for type II and 84% for type III. Preoperative urge incontinence resolved in 81 of 109 patients (74%), while de novo urge incontinence developed in 10 (7%). Intermittent urethral catheterization duration averaged 8.4 days, with 5 women undergoing urethrolysis for a hyper-suspended urethra. Secondary procedures were required in 9 patients with type II and 5 with type III incontinence, and included transurethral collagen injections in 6 and repeat pubovaginal slings in 8. There was a 4% complication rate due to pelvic hematoma in 2 cases, incisional hernia in 2, deep venous thrombosis in 1 and pulmonary embolus in 1. Of the 247 patients 235 (95%) completed the quality of life questionnaire with 92% reporting a high degree of satisfaction with low (less than 20 of 100 points) symptom distress scores.Conclusions: Pubovaginal slings are effective and durable, and significantly improve quality of life in patients with types II and III stress urinary incontinence.